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A prospective Randomized Controlled Trial to Evaluate the Primary Prevention of sudden cardiac death using implantable cardioverter defibrillators in dialysis patients.

The main objective of this study is to assess whether ICD therapy in dialysis patients reduces sudden (arrhythmogenic) cardiac death. The first secondary end point is to compare total mortality death between the two groups. An other is to evaluate…

The efficacy of radioguided occult lesion localisation (ROLL) versus wire guided lesion localisation (WGL) in breast conserving surgery for non palpable breast cancer: a randomised controlled trial

To evaluate the efficacy of ROLL versus WGL in breast conserving surgery for non-palpable breast cancer.

A randomised placebo-controlled trial of
fixed-dose combination medication in people
at raised risk of cardiovascular disease

To measure the efficacy (change in systolic blood pressure and LDL cholesterol) and tolerability of a polypill in individuals with raised risk of a cardiovascular event.

The effect of chronic nocturnal non-invasive ventilatory support at home after ventilatory support during acute respiratory failure in patients with Chronic Obstructive Pulmonary Disease (COPD).

Does chronic nocturnal ventilatory support at home after acute respiratory failure treated by (N)IV lead to a prolongation in time to readmission to hospital due to any following exacerbations in these patients compared to medical treatment only?

Effectiveness of postoperative radiotherapy in patients with oral or oropharyngeal squamous cell carcinoma and histologically confirmed single ipsilateral lymphnode metastasis (pN1)

To determine the optimal therapy for patients with pT1-2 pN0 oral and oropharyngeal cancer

Retention of the posterior cruciate ligament versus the posterior stabilized design in total knee arthroplasty: a prospective randomized controlled clinical trial

To examine whether there is a difference in patients perceived outcome between a posterior cruciate retaining total knee arthroplasty compared with a posterior stabilized total knee arthroplasty.

Effectiveness of repetitive Transcranial Magnetic Stimulation (rTMS) treatment in patients with chronic tinnitus.

To study the effectiveness of low-frequency rTMS in patients with chronic tinnitus.

Cognitive bladder training versus rectal washout training for girls with recurrent urinary tract infections and urinary incontinence

Research question: is primary aggressive treatment of constipation with rectal wash-out in girls with NNBSD at least equally effective as usual care?

Comparing the effects of a new method to prevent constipation according to the usual method to prevent and to treat constipation bij patients lying in the hospital with a neurological disease.

The effectivity of a standard preventing constipation and treatment list, designed by the hospital nutritionteam, will show that neurological patients during their stay in the hospital develop less constipation.

A self-help method for nightmares

The objective of this study is to validate a newly designed self-help treatment for nightmares. This self-help treatment is based on Imagery Rehearsal Therapy. This treatment will be validated in comparison to an exposure treatment a diary condition…

Expert patients as a coach in a self-management program for newly diagnosed patients with diabetes type 2

The primary aim of the study is to answer the following research question: Does selfmanagement coaching by expert patients result in more perceived control over diabetes and a better quality of life in newly diagnosed patients with diabetes type 2?

Preoperative physical therapeutic intervention for high-risk patients who are scheduled for elective total hip arthroplasty

Primary Objective: The primary objective is to investigate the feasibility of a short-term preoperative physical therapeutic intervention for frail elderly patients, who have a higher risk on postoperative complications or a delayed recovery, after…

Comparative, controlled trial of treatment of minor uterine cavity abnormalities diagnosed by office hysteroscopy screening in women indicated for IVF.

To evaluate the impact of treatment of undetected, asymptomatic, predefined uterine abnormalities on the success of IVF treatment

A prospective randomized intra-individual study concerning the effect of postoperative treatment in blepharoplasty patients: The effect of cold temperature, warmth or pressure on postoperative swelling and haematoma.

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Return of fear and the role context: comparing a visual to an olfactory context: Studies 1, 2 and 3

In this research study the role of context in extinction will be investigated in healthy adults in a laboratory setting. Renewal of fear will be compared in two contexts of different modality: a visual context (the illumination of the room) and an…

HARP-trial: *Hand-Assisted RetroPeritoneoscopic live donor nephrectomy versus standard laparoscopic living donor nephrectomy*

To determine the best approach for live donor nephrectomy to optimise donor*s safety and comfort while reducing donation related costs.

Zirconia in permucosal applications: aesthetic, biological and microbiological aspects; a pilot study.

This study aims to investigate the reaction of the peri-implant tissues to these materials when used in oral implant dentistry.

Cost-effectiveness of the Australian Medical Sheepskin for the prevention of pressure ulcers in somatic nursing home clients

To assess the effects and costs of the use of the Australian Medical Sheepskin and usual care with regard to the prevention of sacral pressure ulcers in somatic nursing home clients, versus usual care only.