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Pre-operative protein feeding to stimulate muscle and bone synthesis in older patients undergoing elective hip surgery*

The primary objective is to test the hypothesis that a protein-rich nutritional supplement (containing 45 g of dietary protein) prior to surgery acutely increases skeletal muscle and bone protein synthesis rates in older patients undergoing a hip…

Skeletal muscle atrophy in elderly hip surgery patients during hospital admission

The primary objective is to study the course of muscle (fiber) atrophy in elderly males and females with a fall-related hip fracture or elective hip surgery and the influence of additional nutritional support during hospital admission. Secondary…

The Effect of Creatine Supplementation on Muscle Loss During Immobilisation

The primary aim of this study is to determine the effect of creatine supplementation on muscle mass loss during short-term immobilisation in healthy, young people. In addition, we aim to study the underlying mechanisms of creatine and disuse…

The effects of daily neuromuscular electrical stimulation on muscle mass during long-term unilateral ankle immobilization in adults with ankle fractures

To investigate whether twice daily local (calf muscle) NMES attenuates muscle loss during 2 weeks of unilateral ankle immobilization due to an ankle fracture.

Effects of levosimendan on diaphragm contractility in healthy subjects

The primary objective of this proof of principle study is to determine the effect of levosimendan on the strength and endurance of the diaphragm in healthy subjects. The secondary objective is to gain insight in the neural activation and efficiency…

The effects of daily neuromuscular electrical stimulation during short term one-legged knee immobilization on muscle mass in healthy young men

To investigate the effects of 5 days of one legged knee immobilization with or without daily NMES on quadriceps CSA, lean mass and muscle fiber characteristics.

The impact of dietary protein supplementation and age on muscle mass loss during short term one-legged knee immobilization

To investigate whether elderly individuals lose muscle mass at a greater rate than young individuals during 5 days of one legged knee immobilization, and whether dietary protein supplementation can alleviate such muscle loss in the elderly.

Etiology, diagnostics and management of bruxism

(A) Determine the influence of anger and frustration on self-reported bruxism.(B) Validation of a new ambulant electromyographic (EMG) diagnostic device for bruxism (TeleBrux).(C) Determine the additional value of peripheral modulation with…

The manipulation of dietary protein intake on the anabolic response in healthy young men

STUDY 1: To investigate the impact of prior ingestion of a single high protein meal on the normal obligatory increase of muscle protein synthesis rates after protein intake and physical activity in healthy young men. STUDY 2: To investigate the…

The role of branched-chain amino acids (BCAAs) in the stimulation of skeletal muscle protein synthesis and glucose uptake in healthy, young volunteers

To determine the role of dietary BCAA ingestion and omittance on MPS and insulin sensitivity

The effect of repeated sessions of whole-body neuromuscular electrical stimulation (NMES), with or without subsequent intake of a protein bolus, on muscle protein synthesis in healthy, young volunteers during 3 days of bed rest.

To investigate the effect of multiple sessions of whole body NMES, with or without consecutive protein intake, on muscle protein synthesis.