Search for a trial

Immune effects of acidic and neutral oligosaccharides in the nutrition of preterm infants.

Investigate the effect of acidic and neutral oligosaccharides supplemented enteral nutrition on infectious morbidity, feeding tolerance and short-term outcome in VLBW infants. Furthermore, an attempt is made to elucidate the role of acidic and…

Stress Reduction Intervention during Pregnancy, Length of Gestation, Infant Cognition and the Maternal and Infant Stress System.

Our objective is to test the following hypotheses : - Hypothesis 1 (part 1 of the study): The stress reduction intervention has beneficial effects on subjective maternal emotional well-being, on objective maternal stress system measures (i.e., HPA-…

Modulation of the plasma volume compartment by aerobic exercise in women at risk for hypertensive reproductive complications

Primary objective:• To investigate whether physical exercise prior to pregnancy in formerly preeclamptic women results in a comparable improvement of vascular and endothelial functioning as in women who had an uneventful pregnancy.Secondary…

A randomised controlled trial comparing intra- uterine vesico- amniotic shunting vs. not shunting in the treatment of congenital bladder outflow obstruction.

ObjectiveA high-quality multi-centre randomised controlled trial (RCT) with the following objectives:Primary objective:• To determine if intrauterine vesico-amniotic shunting for fetal bladder outflowobstruction, compared to conservative, non-…

Misoprostol in the management of retained placenta, a safe alternative for manual removal? A randomised controlled trial

To assess the effectiveness of misoprostol in the management of retained placenta. Will 800 micrograms of misoprostol orally reduce the need for manual removal under general anaesthesia and prove to be a safe alternative?

A comparison of pethidine/meperidine intramusculary and remifentanil patient-controlled analgesia during labor in Westfriesgasthuis

The following hypotheses will be tested:Hypothese a: Remifentanil PCA gives a better labour satisfaction than pethidine/meperidine i.m.Hypothese b: Remifentanil PCA gives a better pain-relief during labour, than pethidine/meperidine intramuscularly.…

Towards a new technique for pre-implantation genetic embryo screening in IVF, pilot phase

The objective of this study is to evaluate a new and less invasive method of PGS. The new PGS technique will analyse a nucleus of a blastomere that was obtained by nuclear extraction rather than by biopsy of a whole blastomere.

Prevention of multiple pregnancies in couples with unexplained or mild male subfertility.

1. To prevent multiple pregnancies and the concomittant neonatal mortality and morbidity while retaining acceptable delivery rates in couples with unexplained subfertility or mild male subfertility and poor fertility prospects. 2. To assess the…

Pregnancy Outcomes after Maternity Intervention for Stressful EmotionS - study(PROMISES)

To assess the effects of Cognitive Behavioral Therapy (CBT) in pregnant women with symptoms of anxiety or depression on the child*s behavioral/emotional problems. In addition, we aim to study its effects on the child*s development, maternal mental…

First trimester progesterone therapy to reduce miscarriages in women with a history of unexplained recurrent miscarriages: A randomised, double blind, placebo-controlled, multi-centre trial.

To test the hypothesis that in women with unexplained recurrent miscarriages, progesterone started as soon as possible after a positive pregnancy test ) and continued to 12 weeks of gestation, compared to placebo, increases live births beyond 24…

Costs and effects of fibronectin as a triage in women with threatened preterm labour.

To assess whether testing for fibronectin is a cost-effective strategy that prevents unnecessary treatment in women with threatened preterm labour.

The use of foley catheter results in less interventions as compared to the use of propess

To objective the most efficacy way to ripening the cervix of pregnant women.

Pessaries in mulitple pregnancy as a prevention of preterm birth

To investigate the hypothesis that in women with a multiple pregnancy prophylactic use of a pessary will be effective in the prevention of preterm delivery and the neonatal mortality and morbidity resulting from preterm delivery. To assess in women…

A comparison of remifentanil patient-controlled analgesia with epidural analgesia during labor

The main objective of this study is compare the analgesic efficacy and safety of remifentanil, administered as patient-controlled analgesia (PCA), with epidural analgesia.

Leiden's IVIg trial in Rhesus disease of the Neonate

AimTo determine whether the prophylactic use of IVIg reduces the need for ET in neonates with Rh-D hemolytic disease.

To study the cardiovasculair effects of vasodilatation by nifedipine (Adalat gastrointestinal therapeutic system) with or without plasma volume expansion with Voluven (colloid) in women with preeclampsia

The first aim is to study the cardiovascular effects of nifedipine in pregnancy in patients with preeclampsia. Our second aim is to answer the following questions:Does Adalat GITS with plasmavolume expansion in patients with preeclampsia, lead…

The TOL-study:
The effect of intermittent bolus nasogastric milk feeding versus semi-continuous milk feeding in preterm infants on TOLerance

To asses the effect of intermittent bolus nasogastric milk feeding versus semi-continuous milk feeding in preterm infants

Epidural Analgesia in term nulliparous women with a child in occiput presentation who are allowed a Trial of vaginal labour (EAT)

Epidural analgesia (EA) is an effective method to reduce labour pain. At present, it is unknown whether use of EA increases labour complications, and what the costs of EA are. In this proposal, we assess the impact of a proactive policy of offering…

Differences in maternal temperature and saturation after administration of remifentanil PCA or epidural analgesia during labor

The main objective of this study is to compare changes in maternal temperature and oxygen saturation in patients receiving remifentanil, administered intravenous patient-controlled, with those of epidural analgesia.

Iron and Folic acid v.s. Iron solely in the treatment of post partum anaemia,
effects on haemoglobin and health status

our main objective is to determine whether additional folic acid to ferrous fumarate contributes to the increase of haemoglobin and the improvement of health status in post partum anaemia. Our second objective is to asses what the difference in…