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The effect of low-dose radiotherapy on pain in mild osteoarthritis of the hip

The main objective of this prospective randomized study is to examine the effect of low-dose radiotherapy on pain sensation in patients with early OA of the hip. Our hypothesis is that radiotherapy can achieve a pain-reducing effect of at least 20%…

RAR-CLA and cognition

Daily supplementation of 3.5g RAR-CLA will slow down cognitive decline as compared to placebo

The surplus value of Doppler in Hemorrhoid Artery Ligation procedure.

Standard localized ligations are as feasible as doppler-guided ligations of hemorrhoid arteries.

Clinical trial of dabigatran on airway inflammation and coagulation in severe asthma.

We hypothesize that in patients with severe corticosteroid dependent asthma Dabigatran etexilate will: 1. Reduce airway inflammation; 2. Improve asthma control and pulmonary function; 3. Reduce hypercoagulability in the airways.

Effect of a new synbiotic mixture of short chain galacto-oligosaccharides, long chain fructo-oligosaccharides and Bifidobacterium strain on the gut microbiota of caesarean delivered infants.

The study will investigate the effect of a synbiotic test product compared to a control product on the composition and metabolic activity of the gut microbiota of C-section delivered infants.

The Most Effective Treatment Strategy for Diabetic Macular Edema.

Combined (repeated) laser photocoagulation prolongs time to failure compared to anti-VEGF monotherapy.

Assessment of Perinatal Outcome by uSe of Tocolysis in Early Labour: Nifedipine versus placebo in the treatment of preterm premature rupture of membranes.

The aim of the study is to assess whether in women with early PPROM tocolytics improve perinatal outcome.

PACE Plus trial

Low back pain is common and associated with a considerable burden to patients and society. There is uncertainty regarding the relative benefit of Paracetamol and Diclofenac and regarding the additional effect of pain medication compared with advice…

Dyspepsia - Amitriptyline.

N/A

Fluoxetine and the developing brain.

Administration of fluoxetine during late brain development (adolescence), but not in adulthood, will result in abnormal outgrowth of the 5-HT system. This long-lasting disturbance of the 5-HT system may be visualized using MRI techniques and can…

Effect of intravenous fluid restriction on hospital stay and complications after abdominal surgery: a randomised triple-blinded clinical trial.

A restrictive fluid regimen is beneficial for postoperative recovey after abdominal surgery, as to hospital stay and postoperative complications.

A Randomized, Comparative Trial of Two Posterior Lamellar Keratoplasty Techniques.
Ultrathin Descemet Stripping Automated Endothelial Keratoplasty (UTDSAEK) versus Descemet Membrane Endothelial Keratoplasty (DMEK).

DMEK is superior to DSAEK in terms of (rate of) VA rehabilitation.

Effect of the consumption of a fermented dairy product on
constipation in childhood: a multi-centre randomized
controlled trial.

The study objective is to show that Bifidobacterium animalis is effective in increasing defecation frequency after 3 weeks of product consumption in children with functional constipation.

A prospective double-blind multi-centre trial: Laparoscopic versus open elective sigmoid resection in patients with symptomatic diverticulitis (Sigma-trial).

That the laparoscopic approach should be preferred over the open procedure in cases of an elective sigmoid resection for symptomatic diverticulitis.

Dexamethason for the treatment of exacerbations in multiple sclerosis.

In this double-blind randomized controlled trial, we would like to show that a five-day treatment course with 16mg/day oral dexamethason is effective in inducing recovery from an exacerbation of MS.

Active plus: implementation and evaluation of two tailored physical activity interventions among the over-fifties.

1. It is hypothesized that participation in the Active plus program contributes to an increase in physical activity behaviour among older adults; 2. Additionally receiving physical and social environmental information results in an extra increase…

An exploratory study to evaluate the effect of a new study product on early programming in healthy infants.

The investigational formula will be equivalent to the control formula with regard to the postprandial blood lipid parameters.

The effect of intrathecal methylprednisolone on features of central sensitization in patients with Chronic Complex Regional Pain Syndrome Type 1.

Intrathecal methylprednisolone reduce the features of central sensitization in patients with complex regional pain syndrome type 1 having symptoms longer than 6 months and shorter than 6 years.

Melatonin for children with idiopathic chronic sleep onset insomnia, with or without attention deficit hyperkinesia disorder - A dosefinding trial.
A randomised placebo-controlled double-blind parallel group trial.

Chronic sleep disorders are associated with dysfunctioning during the day. Circadian rhythm disorders are a frequently occurring cause of chronic sleep disorders. The time at which the endogenous melatonin production starts to rise plays a key-role…

Therapeutic Drug Monitoring in HIV-Infected Children Starting a New Anti-Retroviral Regime.

The effect of the TDM strategies on the viral load in terms of change from baseline (start or switch of therapy) to 96 weeks.