85 results
Ticagrelor, at steady state (i.e. after 30 days), will be associated to an improved endothelial function as compared to clopidogrel or prasugrel.
Analyze whether a twice daily regimen is superior to a once daily regime of aspirin when it comes to inhibiting platelet aggregation in cardiovascular patients
Primary Objective• To educate students about the full life cycle of clinical trials including study set-up, design, execution, analysis and reporting• To explore the influence of CYP2D6 polymorphism on the pharmacodynamics and pharmacokinetics of…
The purpose of this study is to advance our understanding of the behaviour of the coronary microcirculation in the setting of NSTE-ACS, to provide insights into the relationship between Doppler flow velocity and thermodilution-derived coronary…
The aim of the study is to demonstrate a basic mechanism that supports our hypothesis: Does increased respiratory function after administration of a bronchodilator in patients with COPD lead to elevated pulmonary retention of the harmful compounds…
The primary objective of this study is to demonstrate non-inferiority by pharmacodynamic (PD) analysis of the prasugrel 5-mg maintenance dose (MD) in aspirin-treated subjects <60 kg with stable coronary artery disease (CAD) versus the…
To study the impact of 3 day exposure to atorvastatin 80mg on Annexin A5 targeting after ischemic exercise in the non-dominant forearm. This to confirm results from our previous study.
: The primary objective of this study is to demonstrate non-inferiority by pharmacodynamic (PD) analysis of the prasugrel 5-mg maintenance dose (MD) in aspirin-treated subjects >=75 years of age with stable coronary artery disease (CAD)…
The objective is to study whether saturated fatty acids induce a different postprandial change in inflammatory markers than cis-polyunsaturated fatty acids.
The major research objective is:- to examine whether elevation of plasma FFAs results in cardiac lipid accumulation and whether this influences cardiac function negatively.Additional research objective: - to examine whether cardiac lipid content is…
The primary objective of this study is to demonstrate non-inferiority by pharmacodynamic (PD) analysis of the prasugrel 5-mg maintenance dose (MD) in aspirin-treated subjects <60 kg with stable coronary artery disease (CAD) versus the…
The primary objective of this study is to demonstrate non-inferiority by pharmacodynamic (PD) analysis of the prasugrel 5-mg maintenance dose (MD) in aspirin-treated subjects >=75 years of age with stable coronary artery disease (CAD) versus…
The main question of this study is: *Is selective beta-blocker treatment safe and effective in reducing sympathetic overdrive, thereby improving RV function and remodeling in patients with iPAH?*.In addition to the determination of RVEF, we will…
The objective of the study is to investigate the effect of PEEP ventilation with or without a recruitment maneuver on right ventricular afterload in infants undergoing cardiac surgery.
To identify which component of hemodialysis is primarily involved in the reduction in myocardial blood flow.
To examine the impact of an exercise bout on the ability to protect endothelial damage in response to ischaemia reperfusion injury in healthy humans. A secondary objective is to explore the potential difference in efficacy to prevent ischaemia…
To examine the effect of remote ischemic preconditioning on exercise-induced cTn elevations and indices of cardiac function.
The primary aim of the trial is to assess what the optimal treatment regimen for acetylsalicylic acid, a statin and two BP-lowering agents is (administered as in regular care in individual agents, a fixed-dose combination pill administered in the…
To examine the acute impact of tea ingestion on forearm resistance artery endothelial function in middle-aged subjects
1. To assess whether acute TRPV1 activation by capsaicin or ENaC down regulation by flavonoids modulate osmoregulation in healthy subjects2. To assess whether capsaicin and flavonoids affect blood pressure