20 results
To investigate responses of the autonomic nervous system (ANS) and facial expressions to sensory-specific satiety.
Overall objective:The overall objective is to test the hypothesis that GLP-1 receptor activation of CNS reward and satiety circuits occurs, in the context of food(-related) stimuli, and that this effect is altered in individuals with obesity and…
To investigate whether the rate of gastric emptying differs between a low viscosity milk product and an iso-caloric high viscosity milk product.
To study the adaptive capacity in relevant metabolic processes after a high fat challenge and oral glucose challenge in humans. It is expected that a test method that is generally applicable in clinical food research can be developed.
To determine differences in food cue reactivity between lean individuals and individuals with overweight. We will study behavioural (food choice, food intake, mood ratings) as well as physiological parameters (heart rate, skin conductance, saliva…
The presently proposed study aims to investigate how dairy proteins compare to vegetable protein and carbohydrate sources leads to glucose and insulin metabolism and substrate partitioning.
The presently proposed study aims to investigate how different feeding frequencies lead to differences in glucose and insulin metabolism in impaired glucose tolerant (IGT) men.
The aim of this study is to determine whether subcutaneous administration of insulin detemir, as compared to NPH insulin, leads to a more pronounced effect on brain glucose metabolism and blood flow in brain regions associated with appetite…
The presently proposed study aims to investigate the effect of feeding frequency on glucose and insulin metabolism and substrate partitioning.
To study whether the lower cholesterol absorption rates of the Dahlia-2a study were due to lower bioavailability of the oral D7-cholesterol tracer.
The main objective is to elucidate the acute effects of an oral intake of either saturated, monounsaturated or polyunsaturated fatty acids on PBMC whole genome expression of obese and type 2 diabetic obese subjects. Secondary objectives are to…
To study the role of central insulin on glucose metabolism.
The presently proposed study aims to investigate the effects of different dairy products, which are frequently used in the Netherlands and not yet analyzed, on Glycemic Index and Insulin Index in humans. This will be investigated by analyzing…
With the current study we aim to assess early brain responses to different food cues (odours and pictures) and we want to determine how these responses are affected by ad libitum intake of product with a specific flavor (sweet/savoury). We expect to…
To determine appetite responses to different odors (signalling different food products), measured by appetite questionnaires, a food preference task, saliva production and food intake
In one of our previous study we demonstrated that enhanced acetate availability in the distal, but not proximal, colon promote fat oxidation, energy expenditure and parameters of substrate and energy metabolism in healthy normoglycaemic men. In…
The primary objective is to assess whether the insulin-stimulated glucose uptake in quadriceps muscle can be improved through 4 weeks of supplementation of clenbuterol.
To assess the acute impact of passive heat treatment on the post-prandial glycaemic response during an OGTT in T2DM patients.
To determine if short-term treatment with the selective beta-2-adrenergic agonist clenbuterol improves glucose disposal via the mTORC2 pathway in lean, healthy male individuals with normal physical activity
The primary objective of this study is to determine whether, oral, or gastric feedback is most important for meal termination (satiation). As a secondary objective we aim to understand how cognitive factors modulate the oral and gastric signals and…