164 results
•To determine the effect of short-term Topiramate treatment on glucose metabolism including endogenous glucose production, whole body glucose disposal and glucose oxidation in obese women. •To determine the effect of short-term Topiramate on lipid…
In this study, the effects of low-fat dairy products on metabolic risk markers in subjects at increased risk of metabolic disorders are determined.
Part I: The objective of Part I of this study is the efficacy of a single 5-g and 10-g dose of InsuVital* on blood levels of insulin and glucose in patients with T2DM.Part II: The objective of Part II of this study is to assess the effect of a 10-g…
The presently proposed study aims to investigate the effects of different dairy products, which are frequently used in the Netherlands and not yet analyzed, on Glycemic Index and Insulin Index in humans. This will be investigated by analyzing…
Objective: To explore whether 1) acute sensory stimulation in the oral cavity by means of alcoholic beverage (=white wine) induces a cephalic phase reflex (CPR)2) prolonged moderate alcohol consumption affects gene expression pathways of…
The major research question is:Does a low-GI food product improve in healthy and obese men postprandial plasma concentrations of inflammatory markers as compared to a high-GI product?Major null hypothesis, H0:In healthy as well as obese men, a low-…
To examine the effects of odors and / or visual stimuli of food in subjects after 56h of starvation on:-Endocrine parameters-Metabolic parameters-Anthropometric parameters-Autonomic nervous system parameters-Hypothalamic function
1. Is prolonged fasting-induced lipid accumulation accompanied by increased levels of DAG and ceramide, which interfere with insulin signaling explaining the insulin resistant glucose uptake.2. Is prolonged fasting-induced lipid accumulation…
Investigate the optimal dose of such an insulinotropic mixture.
To assess the effect of low intensity physical activity on plasma insulin levels, cognition and mood in subjects with overweight/obesity
The objective is to test, validate, obtain regulatory approval for, and deploy at home, a closed-loop Control-to-Range (CTR) system comprising two algorithmic components: a Safety Supervision Module (SSM) and an automated Range Correction Module (…
Primary Objective: Compare achievement of glycemic control in SSI therapy and NPH insulinGlycemic control is defined as the proportion of glucose measurements within target range (Fasting target glucose 3.9 * 7.8 mmol/l. Random target glucose 3.9-10…
Primary objective:•To assess the effect of multiple dose daclatasvir (60mg QD) on the pharmacokinetics (AUC, Cmax, Ctrough, CLr) of multiple dose metformin (1,000mg BID) by intra-subject comparison, in healthy subjects.Secondary objective:•To assess…
The current research proposal intends to study the therapeutic potential of moderate intermittent hypoxia (IH) exposure in subjects at high risk of developing type 2 diabetes, and aims to address the following key objectives:1) To investigate the…
In this study, we will investigate the influence of the amino acid L-arginine, which enhances release of nitric oxide in the body, on BAT activity and metabolism in healthy subjects with overweight. This will increase understanding on the effect of…
The purpose of this studie is to evaluate the bioequivalence of canagliflozin.
Primary objective: Assessment of the impact of the reference glucose measurement on the measured performance of a CGM system, comparing regular venous and arterialized-venous reference glucose samples.Secondary objective: - Assessment of the impact…
This project consists of two related studies. The objective of part 1 is to investigate the effect of elevated plasma lactate levels that are sufficient to impair awareness of hypoglycemia on brain lactate concentrations during euglycemia and…
Primary objective: to investigate the effect of treatment with the SGLT-2 inhibitor dapagliflozin on the awareness of and counterregulatory hormone responses to hypoglycemia in people with type 1 diabetes and impaired awareness of hypoglycemia.…
Primary objective: To examine the effects of calcitriol on the activity of dopaminergic central nervous system regions involved in the visualization and regulation of food intake using functional magnetic resonance imaging (fMRI). Secondary…