28 results
We hypothesize that inhalation of helium gas induces release of protective factors in the blood, which can be used to protect different cell types against ischemia/reperfusion injury.
Primary objective: To determine the safety of once daily inhalation of the recommended daily dose of tobramycin with the Akita® and the PARI-LC® Plus nebulizer in patients with CF. Systemic absorption can be used as surrogate parameter for safety.…
Both hypoxia and hyperoxia can lead to organ damage in preterm infants. For this reason the transcutaneously measured oxygen saturation (SpO2) is kept within a range between 86% and 95%. Hypoxia is mainly caused by immature or impaired control of…
We hypothesize that the circulatory and cardiac effects of TEA will be most pronounced during circumstances of increased sympathicotonus, which will be induced by an exercise test on a bicycle.
The primary objective of this study is to obtain clinical proof of principle that the Addition of a PgP/BCRP inhibitor increases CNS concentrations of tyrosine kinase inhibitors by inhibition of drug efflux transporter function in the blood brain…
The individual counselling intervention will significantly
With a daily activity programme concerning activities of daily life with occupational therapy by volunteers , physiotherapy and ergotherapy , probably functional decline does not develop or the condition of the patients can improve and it can reduce…
The postprandial profile of plasma TG after ingestion of the active product is different to the control.
We hypothesize that black tea ingestion (approximately 530 mg tea polyphenols) in healthy middle-aged humans will lead to a larger mean forearm blood flow response to acetylcholine (i.e. endothelium-dependent vasodilation) We hypothesize that black…
High-output enterocutaneous fistula (>500ml/day) or high-output enterostomy (>1500 ml/day) are associated with a number of complications such as dehydration, malnutrition psychological and wound care problems. Lanreotide inhibits the…
We hypothesize that there is no difference between the survival and follow of the uncemented and cemented ABG THA.
The primary objective of this study is to validate MRI as a functional measuring device for directly monitoring gastric emptying in vivo
Of all babies that die after 25 or more weeks gestation, 40% are small-for-gestational-age (SGA). In the Netherlands third trimester ultrasonography (US) is increasingly being used to monitor foetal growth even though evidence on its effectiveness…
Type 2 diabetes is a major threat to human health. Disruption of the circadian timing system is associated with metabolic changes. Disturbance of the daily light and dark rhythm could contribute to this phenomenon and effects metabolic pathways. We…
We hypothesize that there is no difference between the Day Care surgery pathway compared to the Rapid Recovery pathway in patients operated for unicompartmental knee arthroplasty (UKA).
Pain is an unpleasant experience with a multifactorial aetiology. It is feared by most people undergoing surgery. In the postoperative period pain is controlled using many different drugs. All of these drugs have their own adverse events. Ideally…
There will be no difference between both nails
Lipolysis inhibition during endurance exercise leads to a significantly greater improvement in 24-hour glycemic control in type 2 diabetes, as opposed to endurance exercise under normal circumstances.
For cochlear implanted (CI) patients speech recognition in noise still remains one of the most challenging tasks. One way to improve performance in noise is to benefit from binaural hearing (hearing with two ears). For individuals with residual…