52 results
Primary Objective: The primary objective of this study is to investigate the prevalence EPI in the advanced HF population Secondary Objectives: • To determine the association between exocrine pancreatic function and markers of HF• To determine the…
The primary objective of the CATCA-study is to develop a cfDNA based screening/surveillance tool for colorectal adenoma and cancer, both in the setting of the national CRC screening program and in the surveillance of LS carriers. Additionally, we…
In this study the three-dimensional approach is central in the treatment. The treatment is focused on 1) the child with ASD, 2) the parents, 3) the parent-child relationship, instead of the current one-dimensional approach. Instead of treating…
To determine if re-irradiation in 4 fractions is non-inferior to 10 fractions in the primary endpoint of survival after re-irradiation. Secondary objectives are to establish and compare health related quality of life (HRQoL), recurrence patterns,…
The main objective of this project is to identify the early brain changes in MS (i.e. patients that are recently diagnosed with MS) that can be measured by advanced structural and functional (network) imaging measures. Additionally, we will…
Primary objectives: • To define any alterations in the oral and gut microbiome and metabolome in patients with HNSCC compared to healthy controls;• To investigate the dynamics oral and gut microbiome and metabolome in HNSCC before, during and after…
The primary objective of this study is to investigate whether the use of the EOS calculator safely reduces antibiotic exposure in newborns with suspected EOS in the first 24 hours after birth compared to the current Dutch guidelines.Secondary…
The current project has two goals: (1) to measure viewing strategies used by children with normal vision, children with ocular visual impairment and children with CVI and (2) to evaluate whether training viewing strategies results in more efficient…
The primary objective is to establish the relationship between cognitive impairment and cholinergic neurodegeneration in de novo PD patients, by studying cholinergic imaging using [18F]Fluoroethoxy-Benzovesamicol ([18F]FEOBV) PET and…
Objectives: - To identify and compare motivational behaviour in patients during different phases of cancer treatment. - To test its associations with self-reported fatigue/depression. - To determine to what extent treatment regimen, inflammation,…
The aim of this study is to explore differences in expression of Rac1 and pSTAT3 in leucocytes of therapy-naïve IBD patients, IBD patients on immune suppressive therapy and healthy controls.
(I) Investigating the role of the cholinergic system and CBGTC-loop in the pathophysiology of CD, related to both motor and NMS; (II) Finding a biomarker for DBS efficacy in CD, including motor and NMS.
The objective is to describe differences in MRI patterns in presymptomatic mutation carriers, patients with mild dementia and controls. We will study whether these patterns are specific depending on the type of dementia (FTD/AD) or mutation (GRN/…
To study activity in the reward-circuitry of the brain in patients suffering from cachexia induced by cancer.
1) To investigate what mechanisms underlie the phenomenon of deventilation dyspnoea in COPD patients. 2) To investigate how the change in electrical impedance, measured with electrical impedance tomography (EIT), is related to the change in…
Primary objective:Does the use of the application support a positive lifestyle development?Secondary objectives:Does the use of the application support an increase in physical activity levels?Does the use of the application has a positive influence…
In this study the primary objective is to investigate whether activation of TRPV1, TRPA1 and TRPM3 by selective channel agonists induces vasodilation in human dermal arteries. If the primary objective is achieved, the secondary objective is to…
Primary objective is to investigate the effect of VR on patient-reported pain outcomes in the ED. Secondary objectives are to investigate the effect of VR on analgesics use, patient-reported outcomes, and process indicators and to identify barriers…
Primary: - Examine longitudinal developmental trajectories of structural and functional brain metrics in relation to genetic, clinical, psychological, environmental, and cognitive information in familial high-risk offspring and control children (…
Primary Objectives: 1. To assess the metabolic profile of patients with Dravet syndrome and identify metabolic variations that contribute to the pathophysiology of seizures and developmental delaySecondary Objectives:2. To assess the association…