70 results
The primary aim of the current proposal is to get a better understanding of how CeD risk genes contribute to disease aetiology. To achieve this, we will apply a holistic approach in which we will study the behaviour of immune cells and the…
The BAV study is a clinical and genetic study to unravel biomarker and imaging predictors of adverse outcome and to explore the pathogenetic basis of bicuspid aortic valves and it*s associated pathologies. We will also deliver insights in the…
The first objective of this study is to gain insight in which neurocognitive and neurobiological processes underlie the development of externalizing behavior (in specific aggressive behavior) in the first two years of life. The second objective is…
To establish the incidence and consequences (impairments op body functions, limitations in participation) of traumatic brain injury in children and youth in a region of The Netherlands as well as the incidence of the same symptoms in a group of…
To study prevalence and consequences of cognitive, psychological, social and functional decline in elderly breast cancer patients, in comparison to a population elderly without breast cancer.
Employing PPCM patient-derived iPSCs, we aim to test our hypothesis that cardiomyocytes from PPCM patients exhibit (epi)genetically determined differences in protein expression profiles and functional behavior in comparison to those from healthy…
(i) to determine specificity of Q-detect* for registration purposes. (ii) to design a decision tree for follow-up of patients with a positive Q-detect* and
To establish benchmark values in healthy control fetuses, to compare these with our cohort of fetuses with severe CHD.
ObjectivesOur main hypothesis is that ICP shows a dynamic profile over the course of different attack phases in migraine. Therefore, we aim to detect dynamic changes in ICP in relation to different phases of the migraine attack. In concreto, the…
This study aims to determine the normal distribution of desmosine in a healthy population and a population of patients with COPD (ranging from GOLD I-IV). In addition, the inter-day variation and the correlation with 24-hour urinary desmosine will…
The primary goal of the proposed study is to examine the neural correlates of affective processing in the auditory modality. Specifically, the primary goal is to (1) examine which neural network is specifically involved in the perception of…
Aim of this study is to investigate the clinical performance of two restoration techniques, making use of 'direct' and an 'indirect' composite restorations as a minimal invasive intervention in patients with severe tooth wear.…
We hypothesize that ER stress contributes to epithelial dysfunction in Z-AATD, resulting in enhanced inflammation. In addition, we hypothesize that the airways of Z-AATD patients are particularly prone to bacterial infection and colonization through…
The Primary objective is to quantify the Short Range Stiffness dynamics after stroke in order to quantify the tonic muscle co-activation.
Our overall objective is to better understand the role of regulatory B cells in disease pathogenesis and to better predict disease flares in order to individualize treatment.
This research aims to assess the effect ofn completing an ACA-task on decision-making regarding short-course pre-operative radiotherapy in the treatment of rectal cancer in clinical practice.
To investigate the association between sleep characteristics and glucoregulation (HbA1c) and sleep in patients with DM1.- Is there a relation between sleep characteristics and the quality of glycemic control in patients with DM1*?To compare the…
We will perform a study to describe the echogenicity of the substantia nigra, red nucleus and brainstem raphe in PD patients with and without RLS, RLS patients without PD and healthy controls. The echogenicity will be correlated with the the serum…
In this part of the project we use two 'categories' of test outcomes: false positives and positive test results for a metabolic disease that was not tested. Objectives of the study are to evaluate these categories of test outcomes by…
We propose an instrumented approach, during which the ankle is rotated in a precise and controlled way using a robot manipulator. Using neuromuscular modelling, key neuromechanical parameters as viscosity, stiffness and reflexive torque can be…