85 results
Objective: The aim of the present study is to study the effect of increased adrenaline levels on the inflammatory response (e.g. leukocyte phenotype, cytokines, inflammatory proteins) by administering exogenous adrenaline. Secondary aims consist of…
The primary objective of the current study is to investigate whether self-disgust is heightened in patients with AN. If this indeed is the case, this would provide important leads to improve existing treatment options for AN.
In this study, we therefore aim to investigate how trained immunity is systemically regulated in ANCA vasculitis patients and how the degree of trained immunity affects disease activity and severity. A better understanding of these processes…
The aim is to investigate changes in nocturnal and postprandial glucose and glycogen metabolism in individuals with IFG and IGT when compared to healthy, non-diabetic, overweight participants. In addition, it will be investigated if reducing…
In the current study, the feasibility, acceptability and effectivity of a new add-on early intervention program for individuals at risk for the development of bipolar disorder is evaluated. This intervention program entails psycho-education, light…
The objective of the study is to investigate the feasibilty, acceptabilty, implementation and preliminary (cost-)effectiveness of the intervention on recovery, health and lifestyle variables.
Primary objectives:To evaluate the pathogen host interactions between S. aureus and NS patients:o IgG and IgG4 responses against S. aureus antigens in NS patients will be compared with IgG and IgG4 responses against antigens of other bacteria (e.g.…
Main objectives: 1. Determine whether the POAG patients with low values of the blood mtDNA copy number have a low mtDNA copy number and low mitochondrial function in skin fibroblasts, using in vitro assays of mitochondrial function.2. Explore the…
Identification, segregation analysis, and functional characterization of genetic variants possibly causing rare bleeding disorders. The following questions will be answered:1) Can we identify (new) causal variants that explain the phenotype of…
This study has the following study aims: 1) Investigate whether treatment context and the addition of chronotherapeutic and social rhythm interventions improve the efficacy of BLT, 2) examine the role of circadian phase resetting and changes in…
We aim to provide a neurocognitive account of communicative disabilities in patients with autism spectrum disorder (ASD), focussing on shared representations of a communicative context. We expect that ASD patients show impaired shared…
The aim is to investigate the effect of a multimodal prehabilitation and rehabilitation program in frail patients of 70 years or older, undergoing elective surgery for non-metastatic CRC on1. One-year mortality 2. Postoperative complications,…
This study aims to isolate and culture myogenic stem cells called mesoangioblasts from the muscle biopsies to explore if genetic correction of LAMA2 mutations using CRISPR-Cas9 can be achieved and subsequently assess the effect in vitro, as a first…
Development of a diagnostic algorithm that will diagnose measles cases and classify (potential) contagiousness of patients following measles infection.
In this study we will investigate how safe the new compound LEO 158968 is and how well it is tolerated when it is used by healthy subjects.We also investigate how quickly and to what extent LEO 158968 is distributed and eliminated from the body. In…
Primary Objective: For the primary objective, the following research question is answered: Does performing asleep thalamic DBS provide an equal reduction in tremor compared to awake thalamic DBS, measured by the Essential Tremor Rating Assessment…
This study has been transitioned to CTIS with ID 2023-507052-69-00 check the CTIS register for the current data. To evaluate the long-term safety and tolerability of ARGX-117 in adult participants with MMN
The overall aim of this study is to investigate the pathophysiology of PPMD, and identify predictors of longitudinal outcome.Primary Objective: The primary objective is to investigate the underlying neurobiology of first-onset PPMD using…
The aim of this this study, is to test whether EMDR therapy, relative to a baseline phase, results in: 1) less social anxiety symptoms, and 2) less social avoidance symptoms
In this study, therefore, we aim to investigate how trained immunity is systemically regulated in SLE patients and how the degree of trained immunity affects disease activity and severity. A better understanding of these processes contributes to the…