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Activation of the innate immune system in patients with primary hyperaldosteronism

The primary objective of the study is to determine whether patients with PA have a higher level of arterial wall inflammation than patients with essential hypertension. Secondary Objectives: To determine whether circulating monocytes of patients…

The use of Rienso, an ultrasmall superparamagnetic particle of iron-oxide, as a MRI contrast agent to image inflammation in the atherosclerotic plaque.

In the current study, we want to demonstrate Rienso uptake in the vessel wall in patients with cardiovascular disease and relate the uptake of Rienso to endothelial permeability.

Study to identify the genetic variations associated with phantom limb pain

The primary goals of this study are to: i. Identify genetic variations responsible for PLP across the whole genomeMore than 90% of SNPs are found in introns or intergenic regions and most of them are probably of little functional consequence.…

Ammendment of protocol: Intravenous iron treatment in iron deficient patients with idiopathic pulmonary arterial hypertension. Title amendment: Skeletal muscle strength in healthy persons and patients with pulmonary hypertension

To evaluate the effects of intravenous iron suppletion in iron deficient PAH patients.Amendment: to compare exercise capacity and isolated muscle strength in IPAH patients and healthy controls

Cardiac disease in Ankylosing Spondylitis

Primary objective: To investigate left ventricular diastolic function in AS-patients compared with osteoarthritis patients. Secondary objectives: To assess the prevalence of valvular heart diseases and conduction disturbances. To assess left…

A reproducibility study of novel noninvasive multimodal imaging techniques in atherosclerosis in healthy and cardiovascular diseased subjects

Primary Objectives:A. To assess the reproducibility and variability (interscan, intra- and interreader) of novel (DCE-)MRI techniques to measure vessel wall dimensions, wall shear stress and vessel wall permeability in healthy and cardiovascular…

Prevent CardioKids

The aim of Prevent CardioKids is to evaluate to what extend disturbed vascular function markers are present in children of different weight categories and whether these are age dependent. Also differences * and relationships between * vascular…

Systemic inflammatory response induced by an acute cardiovascular event

The main objective of this study is to assess the effect of an acute cardiovascular event on the local and the systemic inflammatory state in humans with AMI as well as the reversibility of these effects after 3 months.

Medial arterial calcification in patients with hemophilia

The primary objective will be the prevalence of medial arterial calcification, defined as an ABI * 1.3 and a TBI > 0.7, among hemophiliacs compared with non- hemophiliacs matched by sex and age.

Prospective registry of management and outcome of bleeding complications in patients treated with non-vitamin K antagonist oral anticoagulants (NOACs)

Primary objectiveTo assess the outcome of NOAC associated bleeds and emergency invasive surgery or procedures. Secondary objectives1) To describe the treatment of patients presenting with NOAC associated bleeding2) To evaluate the current…

What is the potential diagnostic value of distention and intima-media thickness measurement for the early detection of endofibrosis and is there a link between the development of endofibrosis an the coagulation activation potential of the blood?

1. To investigate a possible increase intimal-media thickness (IMT) is found of the iliacal artery in endofibrosis2. To investigate a possible altered distention is found of the iliacal artery in endofibrosis3. To compare IMT and distention…

Effect of IVF culture medium on health of IVF children

The primary objective is to elucidate whether there is a difference in the outcome of health parameters between IVF children who as an embryo were cultured in two different culture media. As secondary objectives we will investigate how the health…

Incidence of migration and thrombus formation of umbilical venous catheters in infants

Primary objective: to determine the incidence and location of thrombi in the umbilical venous catheter route during and after umbilical catheterization and in the same route in infants without umbilical catheters. Secondary objectives:A. to…

Cardiometabolic consequences of Hereditary Fructose Intolerance

Based on the gaps in our knowledge (as stated above), we have formulated the following objectives:- To quantify the degree of hepatic fat accumulation and fibrosis in patients with HFI. - To gain more insight in the mechanism leading to NAFLD in…

Cerebrovascular manifestations of vascular Amyloid deposition in HCHWA-D | An assessment of the cerebrovascular reactivity in Hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D) patients using Magnetic Resonance Imaging and transcranial Doppler.

The primary objective for this study is to evaluate the cerebrovascular reactivity of HCHWA-D patients:1. To compare the (autoregulatory) function of small brain vessels in HCHWA-D patients with matched controls using the cerebrovascular reactivity…

Human intestinal ischemia and reperfusion

This study aims at (further) revealing the pathophysiology of intestinal IR in man, with a specific interest for the role of proteases and protease-activated receptor-2 (PAR-2), cellular and inflammatory changes, barrier function and intestinal…

Prevention of intimal injury during transradial coronary intervention

To prevent vessel damage of the radial artery by using the Cordis Railway sheathless guiding catheter system.

The effect of periodontitis on innate immune activation and vascular wall inflammation in relation with atherosclerosis

The main objective of this study is to investigate whether a long lasting pro-inflammatory phenotype, the characteristic of trained immunity, is present in circulating monocytes of patients with severe periodontal disease and whether this correlates…

Characterization of ascending aortic flow patterns and vessel wall in patients with aortic valve stenosis before and after surgical valve replacement: a 4D Flow Magnetic Resonance Imaging study.

We aim to i) describe flow patterns and flow-related dynamics in the ascending aorta of patients with aortic valve stenosis, ii) compare these flow parameters before and after surgical aortic valve replacement and iii) compare flow parameters with…

Measurement of local arterial stiffness in the carotid artery in subjects at low and high cardiovascular risk and in patients with recent ischaemic cerebrovascular events.

The main goal of this study is to assess the difference in local pulse wave velocity measured at three different points in the left and right carotid artery in healthy subjects and in patients with symptomatic and asymptomatic carotid plaques. As…