101 results
The objective of the current proposal is to further explore the pathophysiological changes that occur in patient with an IGSF1 mutation, using an established method for assessing hormone secretory characteristics.
1. To explore the validity and usefulness of Bone Microindentation Technique (BMT) in the assessment of bone quality in patients with osteoporosis and a spectre of bone diseases characterised with (localised) increased bone turnover. 2. To study the…
To determine the sensitivity and specificity of salivary metanephrines and in patients with PCC/sPGL.
To assess the impact of treatment with rhGH on circulating Klotho levels in paediatric patients with IGHD.
The aim of this study is to determine whether children between 5-17 years born to women with an autoimmune disorder and prednisone use during pregnancy have chronically elevated cortisol levels compared to children born to women with an autoimmune…
Primary objective:to identify new and improved disease biomarkers and establish the biochemical and molecular basis for variations in the clinical presentation of the different groups of tumors.Secondary objectives:• compare the diagnostic utility…
To understand, from the perspective of the 3-hit hypothesis of psychopathology, individual differences in the neuropsychiatric outcome of previous glucocorticoid (GC) excess in treated Cushing patients.
To assess the presence of GH deficiency in patients who are in long-term remission of Cushing*s syndrome due to adrenal adenoma.
To investigate if there are differences in serotonin transporters in the hypothalamus between subjects with hypopituitarism suspect for hypothalamic damage, subjects with hypopituitarism and no suspicion of hypothalamic damage and healthy age- and…
Development, optimization and implementation of retro-orbital fibroblast cultures in our laboratory.
Objectivesi)) To study whether reproductive hormones play a role in migraine susceptibility in malemigraine patients; ii) to study functionality of the trigeminal system prospectively duringinterictal and premonitory phases of the migraine attack (…
In this study the prevalence and kind of sexual and psychosexual problems will be assessed. Psychological well being is studied as well
Long-term evaluation of thyroid disorders ( TSH elevation and the occurrence of thyroid nodi/carcinoma) in survivors of childhood NBL who received KI, methimazole and thyroxine as thyroid protection during 131I-MIBG exposure. Investigation of the…
To describe the differences in macrophage infiltration and mRNA expression of adipocytokines in subcutaneous, omental and perirenal fat tissue in Cushing's syndrome compared to healthy controls.
The objectives of this pilot study are to explore differences in sleep and fatigue, and the relation with the function of the HPA axis, between survivors of childhood ALL and healthy controls.
The primary study objective is to assess the proportion of patients who remain within the IGF-I age adjusted normal limits with pasireotide LAR (60 mg) monotherapy, after 24 weeks of treatment.Secondary study objectives are assessment of the…
1) To perform gene mutation analysis in family members of patients carrying a proven mutation in the candidate gene.2) To determine the clinical, biochemical and radiological characteristics of carriers of a mutation in the candidate gene.3) To…
To demonstrate differences in intracutaneous sodium storage between a control population, patients admitted after elective cardiothoracic surgery and septic patients.
To investigate the changes in facial- and hand analysis in patients with acromegaly as a result of medical treatment and pituitary surgery, and to investigate the changes in relational proportions between facial- and hand structures, incidence and…
To investigate the effect of androgeninsufficiency on sexual function in women with POI. Also, to map the sexual dysfunction in different domains and compare this data to medically healthy women with sexal problems and medically healthy women…