341 results
To establish whether there are differences in monocyte function in patients with high expression levels compared to low expression levels of microRNA *x*.
The primary objective of the present study is to demonstrate that maintaining sinus rhythm after ECV for persistent AF in patients with severe chronic heart failure and reduced ejection fraction reduces NT-proBNP levels.
The aim of this study is to determine whether the presence and the extent of periodontitis are independently related to the presence and extent of coronary calcification.To determine if periodontal treatment has an positive effect on the…
1) Determine whether humanized mice develop enhanced restenosis upon vascular injury after reconstitution with human PBMCs derived from T2DM subjects with or without macrovascular disease.2) Determine what mechanism(s) induces deranged vascular…
The primary objective is to gain insight into the causative mechanisms of exertional dyspnea in HFPEF. We hypothesize that exercise induced pulmonary hypertension plays a significant role in the development of complaints. The secondary objectives…
The primary objective is to assess the safety of the CardioKinetix Parachute Implant and Delivery System in the partitioning of the left ventricle inpatients with heart failure due to ischemic heart disease.
To compare cerebral activity patterns during emotional and cognitive processing among patients with post-MI depression and patients with regular depression.
Quantify how many frail elderly aged over 65 years with reduced exercise tolerance and/or exercise induced dyspnoea have previously unrecognised COPD and heart failure.Quantify the difference in prevalence of unrecognised COPD and heart failure…
To evaluate the safety and efficacy of the REG1 Anticoagulation System in Acute Coronary Syndrome patients undergoing cardiac catheterization by determination of the clinically acceptable dose range of RB007, which can be used to reliably reverse…
To determine whether different circadian rhythms exist between patients with type 2 diabetes and controls in glucose responses, and whether this difference is best detected by either continuous glucose measurement or venous blood sampling. To…
The aim of this study is to assess whether rivaroxaban, as compared to UFH, on the background of standard dual antiplatelet therapy (DAPT), can effectively suppress thrombosis, and related adverse ischemic events, upon balloon inflation and stent…
Primary objectives:- Evaluation of the value of mBL as a diagnostic tool for bacterial endocarditis.- Evaluation of the value of mBL as a monitoring tool during treatment for bacterial endocarditis.- To obtain data on the kinetics of mBL related to…
To investigate whether patients with hemophilia A develop less coronary artery atherosclerosis as compared to non-hemophilic males.
The aim of this study is to develop and evaluate a shared care survivorship care plan (SCP) to follow-up patients with metastatic testicular cancer after completion of chemotherapy that resulted in complete remission.
The primary objective of this study is to identify mutations associated with the development of a bicuspid aortic valve. To this end the study will focus on genes important for aortic valve formation. As an extension of the primary objective, a…
To predict the risk of particular coronary plaques to cause myocardial infarction
1) To demonstrate an elevated troponin concentration before exercise and a rise of troponin after exercise in both pre-clinical HCM mutation carriers and HCM patients with the hypertrophic phenotype, 2) To evaluate the troponin rise in relation to…
1) Determine differences in EPC and SMPC availability in the peripheral blood of T2DM patients with or without coronary artery disease (CAD) or peripheral artery disease (PAD) as well as in age- and sex-matched non-diabetic subjects with or without…
The aim of the present study is a performance evaluation of INNOVANCE® PFA P2Y. The first objective is the determination of a reference interval for the Intended Use Population (patients eligible for Clopidogrel therapy). This will be done by…
The primary objective is to investigate if a salt-reduced diet leads to an increased reward response when exposed to lower salt concentrations in food.