341 results
The primary objective of the study is to explore the efficacy of intensive bicycle exercise test to induce cardiac micro-injuries by measurement of serum concentrations of hs-troponin I in healthy volunteers. The secondary objectives of this study…
Main objective:Have formerly preeclamptic women, 5 to 10 years post-partum, a higher prevalence of a cardiovascular riskprofile compared to women with uncomplicated pregancies in history.
The primary objective of the study is to investigate the effect of sunitinib on ex-vivo atrial contractile force in absence and presence of ischemia-reperfusion. A secondary objective is to explore if atorvastatin or AICAR prevent sunitinib-induced…
To investigate whether the expression of renal water and sodium transporters in urinary exosomes is different in compensated versus decompensated liver and heart disease.
This study finally aims to provide hospitalized coronary heart disease patients who smoke with proven (cost)effective smoking cessation interventions. Point prevalence abstinence is estimated in the experimental groups at 60% at 6 months, against 43…
Primary objectives1. To investigate prospectively the prevalence of cardiovascular damage due to cancer treatment and it*s change over time.2. To investigate markers of early and late toxicity of cardiovascular damage due to cardiotoxic treatment.…
As for the equipment: various investigations will concentrate on the reliability of blood glucose measurment equipment an pumps for CSII at altitude.Furthermore, total insulin requirements, energy expenditure, and glucose curves will be closely…
To demonstrate the safety, efficacy, and performance of the Edwards Lifesciences MONARCTM system for the treatment of functional mitral regurgitation
a) To investigate the differences in adipokines and inflammatory markers between obese and normal weight children; b) to study these differences over age, and c) to correlate adipokine/inflammatory marker profiles to clinical parameters for obesity…
ObjectiveThe overall goal of this project is to identify the specific genomic markers associated with severe anthracycline-induced cardiotoxicity to be able to identify high-risk patients. The specific objective of this proposal To validate and…
To establish whether miRNA expression patterns in platelets, monocytes and plasma differ between subjects with premature CVD and a positive family history of premature CVD as compared to age en sex matched healthy controls.
Hypothesis:1. Patients who suffer from a hypopituitarism and an adult-onset growth hormone deficiency (AGHD) express more atherosclerotic disease in the coronary system (compared with a historically formed control subjects, present as a database in…
To evaluate whether an increase in inflammatory- and coagulation parameters can be found in healthy volunteers with elevated hsCRP levels compared to age and BMI matched healthy volunteers with normal hsCRP levels
Our primary objectives are to evaluate - if endogenous EPO, EPC levels and EPC function are different in patients with stable and unstable CAD, compared to age and sex matched controls;- if a correlation exists between endogenous EPO and EPC levels…
The primary aim of this study is to assess the applicability of RT3DE for the evaluation of left ventricular function in daily clinical practice of a pediatric cardiology service.
Objective: We aim to assess whether [1] epigenetic alterations are responsible for the detrimental effects of maternal undernutrition during gestation on the offspring*s (F1) cardiovascular health, and [2] these epigenetic alterations pass down…
1. To determine if beta2-receptor polymorphisms influence the probability of recovery of heart failure.2. To determine possible other factors that influence the probability of recovery in our patient cohort.3. To determine the amount of LVEF…
Primary Objectives: To prospectively investigate the changes in cardiac parameters (echocardiography, NT-pro-BNP) and uteroplacental flow (pulsatility index, diastolic notching) during/after pregnancy in women with CHD and compare these changes with…
1. To evaluate whether patients with FCH have different pattern of hypothalamic neural activity compared to healthy control subjects, 2. To evaluate whether patients with FCH (index patients) have a different pattern of hypothalamic neural activity…
1) To assess whether a correlation exist between the degree of pulmonary clearance of free radical positive white bloodcells and platelets and the degree of pulmonary congestion in congestive heart failure (CHF) patients2) To asses whether cardiac…