51 results
DEfective HUman SAlivary gland stem cells: the cause of Primary Sjögren*s syndrome?
-DEHUSAPS study-
To assess whether salivary gland stem cell (SGCS) defects are key to salivary gland pathogenesis in pSS.
• To increase the sensitivity of the current MRI methods for detecting the changes caused by NPSLE through the scans made on the 7 Tesla scanner, since the higher field strength will lead to a higher signal to noise ratio and higher resolution. • To…
-To determine the feasibility of detection of synovitis by photoacoustic imaging using three discrete wavelengths of pulsed light as an early indicator of the presence of RA.-To correlate the photoacoustic markers that are indicative for…
- To determine whether there is a mitigated immediate immune response to islet infusion in immunosuppressed recipients- To determine if complement activation during immediate immune response is affected in immunocompromised recipients
The aim of this pilot study is to establish Th1/Th2/Th17 patterns in healthy controls by analysing cytokine concentrations in nasal fluid (nasal wash and cotton wool method), saliva and blood. This will be done in order to give an estimation about…
Our primary objective is to identify de novo/rare mutations causative of MS using WES in members of multi-incident families. Our secondary objective is to describe phenotypes per family using questionnaires and semi-structured interviews with family…
Primary Objectives: 1.1: To evaluate the feasibility of determining sensory thresholds in patients with JIA using QST.1.2: To examine which sensory modalities are particularly affected in JIA patients compared to healthy controls in order to define…
The aim of the study is to identify patients with selective gamba-allergy and sensitization patterns for the various allergens in gamba extracts. Comparing sensitization patterns between patients who clinically react to Gamba with patients having a…
To investigate the impact of high field 3T MRI on the diagnostic criteria in MS in a large multicenter study population using multiple vendor MRI systems.
The aim of this study is to investigate immune response to pneumococcal vaccination in patients after community acquired pneumonia with S. pneumoniae compared to pneumonia patients with another pathogen.
This study aims to determine whether the ILC populations differ in the lungs of different phenotypes of asthmatic patients and healthy subjects and how these cells are regulated by bronchial epithelial cells. Furthermore we want to study how this is…
The aim of this MRI study is to understand how neurodegeneration in MS (in vivo) is related to other facets of MS pathology, i.e. inflammatory (T2) lesions, black hole (T1) lesions, cortical lesions and damage of the normal appearing brain tissue.…
The aim of this study is to provide evidence that the electronic nose is able to discriminate between the groups that are mentioned above in a cross-sectional study.
1. Validate and adjust the current classification criteria for systemic vasculitis2. Develop and validate new diagnostic criteria for systemic vasculitis
We hypothesize that an electronic nose can discriminate between the exhaled breath of patients with established pulmonary sarcoidosis from healthy controls Secondly, we hypothesize that an electronic nose can discriminate between different stages of…
Our aim of the study is investigate IL-7, TSLP and CD30(L) expression in SLE patients en healthy controls to better understand pathogenesis and to find a biomarker that is related to disease activity.
This research aims the usefullness of duplex mapping in systemic giant cell vasculitis. In determing the diagnosis, the duplex will be compared with the current gold standard, the 18F-FDG PET-CT, looking at the sensitivity and specificity of the…
To study the validity and usefulness of three immunological assays to improve knowledge on the course and diagnosis of sesame seed allergy in sesame seed allergic patients with proven anaphylaxis. In the first place, the CAP inhibition assay is used…
The objective of this study is to understand the patient perspective on remission in RA.
To answer the following questionsDo RA-specific autoantibodies cross the placenta, and can they be found in fetal cord blood in the offspring of mothers suffering from RA?Do RA-specific autoantibodies in fetal cord blood display different…