187 results
The objective of this study is to investigate the intra-individual change in AMH levels over several years in female RA patients.
To assess the feasibility of measuring a course in ischemia and endothelial activation in antecubital venous blood during cooling and recovery in patients Raynaud*s phenomenon, primary and secondary to SSc with and without Pulmonary Arterial…
The aim of the project is to validate biomarkers for the development of a peripheral blood test which can distinguish early inflammation between various forms of IBD, with the use of novel techniques, such as mass cytometry and RNAseq.
1. To study reproducibility of a qualitative scale for abnormality of brachial plexus MRI.2. To study usefulness of quantification of nerve size using maximum intensity projection techniques (MIP) , and compare results with HRUS of the brachial…
Primary Objective:Delineate the differences in cellular composition and function at the maternal-fetal interface in patients with SLE compared to healthy women Secondary Objectives:- Establish a novel in-vitro model to study cell-cell interaction at…
Primary Objective:To evaluate the efficacy potential, safety and tolerability of intravenously administered ANXV, in ascending doses, and two different dosing regimens, in patients with confirmed moderate to severe COVID-19.Secondary Objectives:To…
To demonstrate non-inferiority of a T2T strategy in which conventional synthetic disease modifying drugs (csDMARDs) refractory RApatients are initially treated with tsDMARD baricitinib versus the comparable T2T strategy in which patients are…
1) To study the effects of antibody removal by immunoadsorption on the immune phenotype over time in patients with B-cell related autoimmune diseases such as MG, AAV, anti-GBM disease, cryoglobulinemic vasculitis and other refractory antibody-…
We aim to find immune defects and related genetic variants in patients who have recovered from secondary HLH
The aim of this study is to better understand various prerequisites for the development, implementation, and immunological monitoring of immune regulation restoring therapies in RA patients. To meet this aim, the study is divided into four equally…
Primary Objective: 1. to determine unique inflammatory VOC profiles that distinguish patients with PAH-CTD, CTEPH and IPAH from SSc and SLE (CTD) patients without PAH. Secondary objectives:1. to test whether these unique inflammatory VOCs associates…
Main Objectives: To collect clinical data and biological samples derived from blood (plasma, serum, cells and DNA) as well as urine and stool to perform multi-omic and functional biological assays. The resulting data will be integrated and analyzed…
The primary objectives of the study are as follow:1) To assess usability and adherence to a T2T strategy implemented through a digital e-health tool website (i.e. do physicians work through all aspects of the website and take part in all the T2T…
This study has been transitioned to CTIS with ID 2024-518966-28-00 check the CTIS register for the current data. The primary goal of this study is to investigate the effects of belimumab on the composition of lymph nodes and the inflamed synovial…
This study has been transitioned to CTIS with ID 2024-511115-25-00 check the CTIS register for the current data. Primary Objective:The primary objective of this study is:• To evaluate the efficacy of namilumab in subjects with chronic pulmonary…
Overall aimIdentify immunologic imbalances, with a focus on IFN, NETs, complement and lymphocyte subsets during pregnancy in women with systemic autoimmune diseases.HypothesisWe hypothesize that increased IFN activation and NET formation in patients…
To investigate the tolerability and effect of pure cafeine food suplement pre-administration on myocardial [18F]FDG uptake suppression.
The first aim of this study is to use an in vitro approach using patient*s derived material to accurately and rapidly predict the optimal therapeutic approach that will predict a good clinical response in individual patients. The second aim of this…
Objective1) Validate the biomarker potential of CXCL10, TNFR2, and galectin-9 in disease activity monitoring of JDM and DM.2) Determine the role of IL-18, CCL2, CCL4, CCL19, CCL27, CXCL10, CXCL13, TNFR1, TNFR2, galectin-9 and other potential…
1. to describe NVC findings in patients with pediatric (systemic) auto-immune/-inflammatory diseases:- Juvenile systemic/localized sclerosis (jSSc/lSc)- Childhood-onset systemic lupus erythematosus (cSLE)- Juvenile dermatomyositis (JDM)- Juvenile…