271 results
The aim of this study is to determine the risk factors in infants for obtaining a severe HPeV infection. For this purpose, we will test the hypothesis that (maternal) HPeV specific antibodies are protective against (severe) HPeV infections in young…
With this project we aim to clarify the differences in airway pathophysiology between asthmatics and healthy controls that underlie the prolonged survival of virus and the exaggerated inflammation in virus-induced exacerbations of asthma. We will…
Objectives: • Primary objective (parasitological): To explore the longevity of immunity against P. falciparum sporozoite challenge that was induced in the EHMI-8 study. • Secondary objective (immunological): To dissect mechanisms of protection and…
The primary objective is whether a difference in innate and acquired immunorespons on RSV infection exists, in children with DS compared to healthy matched-controls.
Objective of this study is to provide evidence for the induction of AGEs in blood and tissue in patients with septic shock.
Primary objectives:(1) To describe the incidence of EV and HPeV infections in Dutch children(2) To determine the major symptoms of EV/HPeV infections in children(3) To evaluate the epidemiology and symptoms of the different subtypes of EV and HPeV(4…
The objective of the standardized protocol is optimalizing the accuracy of the diagnosis (all-cause pneumonia, or serotype-specific pneumonia) during the 13-valent pneumococcal vaccin (13vPnC) study which will be performed in 2008. Additionaly, the…
To determine the effect of probiotics (microbial food supplements) on acquisition rates and colonization prevalence of CC17 ARE in two wards where ARE-colonization is endemic.
1.) Is the gut flora of the healthy infant on day 3, day 7 and day 28 originally from the mother or the environment?2.) Is the process of colonizing in healthy term infants dependent on the mode of delivery?3.) Does breast milk contain bacteria and…
Characterization of T cell responses in young children after influenza infection
The objective of this study is to identify determinants, to determine the transmissibility and to determine the burden of disease of NT-MRSA and CA-MRSA carriage compared to other typeable MRSA strains in the community.
To determine the general usefulness of and a proper moment when blood should be taken for the in vitro IFN-γ assays in patients undergoing chronic haemodialysis.
Effect of Coxiella burnetii infection on health status of patients following an outbreak of Q fever.
To determine the health status of the patients of the Q fever outbreak in the Netherlands in 2007, one year after primary Q fever infection.
To evaluate immune function and (the susceptibility for) oxidative damage under the influence of long-term olive-oil based TPN use in patients without an active underlying disease and compare this with findings in healthy controls
CD8 T-cell expansions in HIV patients, treated with HAART, who have long-term suppression of HIV-RNA
To determine the nature of these expanded CD8 T-cell subsets, by performing apoptosis resistance assays and phenotypic analysis of markers that are primarily found on so-called exhausted cells.
to establish the accuracy with which the eNose can discriminate patients with invasive pulmonary aspergillosis from controls
Primary objective: To determine the dynamics of MRSA carriage in persons working on or living at pig and veal farms.Secondary objectives: To determine the amount of disease associated with carriage of MRSA-CC398. To determine the role of exposure to…
To set up a cohort of HIV infected MSM who subsequently acquired HCV infection with a known date of HCV seroconversion to study:- determinants/risk factors for acquiring HCV in HIV infected MSM- the outcome of HCV treatment in this population- the…
The general objective of this study is to elucidate the cellular components for HIV-1 infection in children.
The objective of this research is to identify genetic host factors influencing the clinical course and treatment of HIV infection. The identification of these genes may lead to new therapeutic or preventive approaches. In addition, the…