271 results
To examine the transmission of HIV variants.Have 1 or more viruses been transmitted?To examine the course of HIV-infection. Are differences in the course of HIV infection with same type viruses caused by genetic hostfactors Course more unfavourable…
Our preliminary data shows that the prescription rate of antibiotics for suspected EOS versus blood culture proven EOS was high. We aim to develop a new diagnostic model to reduce unnecessary antibiotic treatment which can be tested in the near…
The aim of our study is the development of a simple device that is able to differentiate between sputum from TB patients and non TB patients.With the knowledge and concentration of the VOCs from M. tuberculosis and possible the specific host…
The primary objective of this study is to determine the anti-inflammatory potential of mechanical auricular Vagus nerve stimulation in healthy humans.
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The hypothesis of this study is that children that are vaccinated since birth will have significant less or no cross protective CTLs compared to children that have not been vaccinated since birth. Objective: Determination of the effect of annual…
Primary:To determine trends in vaccine- and nonvaccine-serotype S. pneumoniae asymptomatic colonisation in healthy 11-month-old and 24-month-old infants who have been immunized according to the Dutch NIP with 7-valent pneumococcal conjugate vaccine…
Characterization of the effects of ageing on the innate immune response against influenza.
Establish relevance of a clinical scoring system, and of established and to be identified biomarkers in blood and urine for clinical course and clinical and microbiological outcome of patients with a complicated urinary tract infection, treated in…
How long does B-cell memory persist after a single conjugate MenC vaccination and which cells are involved? How is this related to the age of first vaccination? And how to define correlates of protection for immunity and memory after MenC conjugate…
To make a risk estimation of the risk for public health, research is needed about:1. How many Ae. Albopictus are being introduced in the Nederlands?2. Does Ae. albopictus settle permanently in the Nederlands? If yes, where?3. Do the imported…
Objective of this study is to investigate cytokine production and expression of toll-like receptors on monocytes in blood samples from pregnant and non-pregnant women using sonicates from different types of oral pathogenic micro-organisms and…
The aim of our study is to validate serology as well a PCR assay using culture as the goldstandard.
Overall aim: To study the influence of M.leprae antigens on differentiation and maturation of DCs and to identify M.leprae antigens, receptors on antigen presenting cells and signaling pathways which play a role in leprosy pathology. Main objective…
Aim of this study is to investigate the effects of oral administration of GTS-21 in healthy volunteers on cytokine release in ex-vivo TLR agonists stimulated whole blood . Pharmacokinetic and pharmacodynamic data will be collected with respect to…
It is therefore planned to study pain perception in peripheral neuropathy in the context of positive and negative emotional stimulation. Although there is a recent plea for the study of emotional modulation of pain, only one study has as yet done so…
The primary objective of this study is to determine the prevalence of V-MRSA in areas with high density of pig farming compared to the expected prevalence of MRSA in the general population of The Netherlands and as a secondary objective to assess…
The aim of this pilot implementation is first to make a serious start in Chlamydia screening and secondly to determine feasibility, affectivity and cost-effectivity. The results of this pilot implementation will be leading for the decision about the…
In this pilot study patients treated with a single course of rituximab or treated with multiple courses of rituximab, matched RA controls treated with methotrexate and healthy controls will be included in order to answer the following questions:1.…
To determine and compare the periodontal status between the different groups of women. Periodontal examinations will be performed within one week after delivery. If periodontal disease is diagnosed within the selected groups, it is plausible to…