271 results
Primary objective: To determine the added diagnostic value of the lytA qPCR on samples of the upper respiratory tract on top of routine microbiological tests in detecting pneumococci as responsible pathogen in patients with CAP.Secondary objective (…
To determine the impact of prior BCG vaccination on the duration of immunogenicity of the BioNTech/Pfizer mRNA COVID*19 vaccine.
Primary objective:Investigate if a trained immunity profile in innate immune cells might be a mechanism of HIV elite control.Secondary objectives:1. Determine the immune phenotypes that distinguishes family members of HIV elite controllers from…
Primary Objective:To evaluate the efficacy potential, safety and tolerability of intravenously administered ANXV, in ascending doses, and two different dosing regimens, in patients with confirmed moderate to severe COVID-19.Secondary Objectives:To…
Objective: To investigate the adipose tissue response upon ex vivo SARS-CoV-2 infection, more specifically to answer the following questions:1. Is adipose tissue permissive to direct SARS-CoV-2 infection? 2. Are adipose tissue-derived factors…
Development of a diagnostic algorithm that will diagnose measles cases and classify (potential) contagiousness of patients following measles infection.
To assess the effectivity and feasibility of HCV RNA self-testing in reducing the time to diagnosis of HCV re-infection in MSM previously cured of an HCV infection, compared to the current diagnostic standard of care. To evaluate whether the uptake…
Identification of T cell epitopes that will serve as the basis for a novel Q fever vaccine with fewer side effects. This will be done by determining ex vivo the effect of Cb-derived T cell epitopes on IFN-γ production in blood of healthy volunteers…
We aim to find immune defects and related genetic variants in patients who have recovered from secondary HLH
1. Primary objective: - SARS-CoV-2 binding (expressed as concentration of virus bound in pg/mL) to epithelial cells isolated from nasal cavity between intervention and control groups (every volunteer is his own control group, depending on nostril).…
1. To evaluate if breastmilk of mothers who recovered from a proven COVID-19 infection contains antibodies (IgA) against SARS-CoV2.2. To evaluate if these antibodies are still present after pasteurization according the Holder method.
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Primary Objective: To prospectively compare outcomes of subjects with diabetic foot osteomyelitis treated with antibiotics targeted at culture results from bone biopsy (intervention group) versus therapy targeted at ulcer bed biopsy culture results…
This study is designed to dissect the immune response after Bp booster vaccination by investigating the kinetics of innate and adaptive immune cells, and detection and characterization of Bp-specific memory B cells and plasma cells.
Therefore, the Precision Medicine for more Oxygen (P4O2) program aims to identify treatable traits and innovative personalized therapeutic strategies to both prevent progression of early stage lung damage and to reverse established lung damage by…
Main study: primary vaccination regimenPrimary Objective: 1. To determine the difference in the antibody response against SARS-CoV-2 in PLWH 4 weeks after the completed vaccination schedule with one of the two available mRNA vaccines (BNT162b2 or…
The objective of the current study is to evaluate the performance of two new formats of the IGRA using pre-filled antigen formulations in a cohort of Dutch individuals with known prior exposure to Cb.
The primary objective of this study is to investigate whether the use of the EOS calculator safely reduces antibiotic exposure in newborns with suspected EOS in the first 24 hours after birth compared to the current Dutch guidelines.Secondary…
This study has been transitioned to CTIS with ID 2024-515263-60-00 check the CTIS register for the current data. - A. What are the SARS-CoV-2 viral load kinetics during and after treatment with neutralizing monoclonal antibodies and other antiviral…
The aim of the study is to determine whether children who have been admitted to the ICU for an RSV infection in their first year of life and now are at school age:1. have more respiratory complaints than controls (based on a short questionnaire…