42 results
Primary objective: To compare the NP microbiome composition and the presence of viruses in children hospitalized for a LRTI to the NP microbiome composition and the presence of viruses in healthy age- and gender-matched controls. Secondary…
In order to confirm previous observations and to increase our understanding of the patho-physiologic mechanism of the plasma lipid changes; in this study, we will prospectively measure the blood lipid profile of approx. 120 malaria patients and an…
The generic objective of the study is to explore associations between exposure to livestock farms and potential health effects. This study will focus on 1) respiratory health effects, 2) Livestock associated infections (zoonoses), 3) Carriage of…
To investigate the release of damage-associated molecular patterns (DAMPs) following major hepatic resection with or without VIO and to correlate the outcomes to the acute inflammatory response and clinical parameters for hepatocellular damage.
Primary Objective: To compare the expression of inhibitory receptors SIRL-1 and LAIR-1 on blood neutrophils of patients under age 12 admitted with sepsis to the paediatric intensive care with healthy controls and intensive care patients without…
The aim of this study is to evaluate the predictive value of a blood cell derived score, ICIS, for microbial infection, its likelihood, its invasiveness (blood stream infection) and severity (septic shock or mortality) in patients after lung or…
To determine the choline levels of FNH, HCA and HCC using proton Magnetic Resonance Spectroscopy (expressed as parts per million).
To assess efficacy and safety of temoporfin (Foscan*) photodynamic therapy in the treatment of locally advanced perihilar bile duct carcinoma without distant metastases.
We will examine the activation status of platelets, the content of platelet granules, and activation of de novo synthesis of mitogenic proteins during and after a partial liver resection in patients with a malign or benign tumor including distant…
The trial aims to investigate whether procalcitonin measurements can reduce the amount of blood cultures in the ICU safely and cost-effectively.
Our primary hypothesis is that the process of nasopharyngeal and fecal colonization from birth to childhood differs in quality and quantity between infants with CF and healthy controls and that these differences are related to subsequent respiratory…
The aim of the study is to test the hypothesis that susceptibility to and severity of certain infectious and inflammatory diseases can be explained by the interaction between the genome, microbiome and immunological responses: i.e. presence of…
To evaluate the outcome of FISH testing with a set of biomarkers with regard to the prognostic value and the diagnostic accuracy for both sporadic cholangiocarcinoma and PSC related cholangiocarcinoma. Subsequently we want to develop a valid…
This study has two goals:1. Investigate the cellular and humoral immune response of immune compromised travellers compared to the healthy traveller.2. Investigate the epidemiology of travel related infectious diseases in a population of dutch…
To evaluate the incidence, risk factors and perinatal morbidity and mortality due to CA after TTTS treated with fetoscopic laser surgery.
To investigate the relation between a known genetic variation in a set of selected genes involved in the recognition of microorganisms and inflammation and the frequency of respiratory tract infections in a group of children with DS.
To investigate whether local inflammation in the area of the stomach and gastroenteric anastomosis is a cause of primary DGE.
To screen two different formulations of the recombinant malaria vaccine PfLSA-3-rec, one adjuvated with aluminium hydroxide and one with Montanide Isa 720, by assessing the safety and immunogenicity (phase I) profile of each formulation in humans,…
Within the observational study WP9, there will be 3 substudies. First the microbiological aetiology of LRTI will be studied by comparing test results in 3000 healthy controls to findings in 3000 adults with LRTI. Bacterial resistance rates will be…
To establish efficacy of pre-travel vaccinations by determination of protective serum antibody titres against hepatitis A, DTP and polysaccharide Vi of Salmonella typhi. To quantify health risks related to preventive actions and consequences of…