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Acute lipid profile changes in malaria patients - a gateway towards novel antimalarial drug class identification?

In order to confirm previous observations and to increase our understanding of the patho-physiologic mechanism of the plasma lipid changes; in this study, we will prospectively measure the blood lipid profile of approx. 120 malaria patients and an…

The Intensive Care Infection Score to predict microbial infection and its sequelae in critically ill lung and heart transplant patients.

The aim of this study is to evaluate the predictive value of a blood cell derived score, ICIS, for microbial infection, its likelihood, its invasiveness (blood stream infection) and severity (septic shock or mortality) in patients after lung or…

Procalcitonin to guide obtaining bloodcultures in the ICU.

The trial aims to investigate whether procalcitonin measurements can reduce the amount of blood cultures in the ICU safely and cost-effectively.

Fluorescence in situ hybridization in the early diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis

To evaluate the outcome of FISH testing with a set of biomarkers with regard to the prognostic value and the diagnostic accuracy for both sporadic cholangiocarcinoma and PSC related cholangiocarcinoma. Subsequently we want to develop a valid…

Identifying new biomarkers for sepsis diagnosis with proteomics techniques

To identify new blood based protein biomarkers for the diagnosis of sepsis.

Personalised Risk assessment in Febrile illness to Optimise Real-life Management across the European Union (PERFORM)

This study aims to improve the diagnosis and management of febrile children across Europe and West Africa through the development of simple diagnostic tests to discriminate febrile illnesses in children, including bacterial and viral infection and…

the Application of Exhaled breath aNalysis in the Early detection of ASpergillosis

To determine the accuracy with which patients with probable or proven invasive pulmonary aspergillosis and neutropenic controls can be discriminated from each other, as measured by the values of the sensitivity, specificity and accuracy.

Diagnosis and Management of Febrile Illness using RNA Personalised Molecular Signature Diagnosis

Our proposal builds on 12 years of sustained EU funding, a consortium covering 11 European countries and 27partners (with non-EU sites in African and two Asian populations to provide a global perspective) and our cuttingedge new research, which has…

Detection of sepsis at the intensive care unit with non-invasive transcutaneous blood gas monitoring.

The primary objective of this study is to determine the accuracy of the delta PCO2 (PaCO2-tcPCO2) and delta PO2 (tcPO2 -cPO2) levels for the detection of sepsis. The secondary aims are to determine the factors that influence delta PCO2 and delta PO2…

Neutrophil granulocyte membrane-based biomarker discovery for discrimination between acute bacterial versus acute viral infection: a pilot study.

Identification of host biomarkers, being membrane bound proteins, on both neutrophils and CD64 expressing cells, that have discriminatory difference in concentrations.

Diagnostic intervention study of low-dose CT and multiplex PCR on antibiotic treatment and outcome of community-acquired pneumonia

The aim of this study is to determine the added value of low-dose CT and PoC-PCR in the diagnostic workup of patients with CAP hospitalised to non-intensive care unit (ICU) wards in minimizing selective antibiotic pressure while maintaining patient…

Next generation sequencing of pathogens in neonates suspected for sepsis

Observational pilot study to investigate NGS as a reliable method to identify sepsis in neonates. NGS is proposed as a method to improve clinical identification, diagnosis and stratification of neonatal sepsis and provide basis for a more adequate…