26 results
Objective: We want to extend our understanding of the disease aetiology by performing a small pilot study that incorporates other immunologic sites involved in the disease (the skin and the microbiome) while additionally strengthening our disease…
The main objective of the study is to document cardiovascular dysfunction found in rheumatoid arthritis and gout patients using cardiac imaging techniques echocardiography and cardiac MRI.
To determine whether nonspecific triggering of monocytes is associated with different epigenetic programming and expression of pro-inflammatory cytokines in clinically suspect arthralgia and in RA.
Previous studies [10] have proposed that cartilage degeneration due to obesity could be caused by changes in the joint kinematics during ADL that shifts the loading applied to cartilage. Such a shift may cause regions of cartilage to become newly (…
The primary objective in this study is to detect the presence of supra-spinal central sensitization in patients with chronic neck pain secondary to cervical facetal arthropathy. We aim to show this by comparing the pressure-pain thresholds (PPT; the…
Primary Objective: To investigate which underlying muscle properties can explain (expected) differences in strength between subjects with and without OA, and how muscle strength, voluntary activation and fatigability are related to function.…
The main hypothesis is that circulating inflammatory mediators are the main causative factor for the emergence of generalized osteoporosis in patients with Rheumatoid Arthritis (RA). 1.Does the serum of patients with active RA, containing…
The objective of this study is to investigate whether decreased variability in trunk-rotations during gait in CLBP patients can be attributed to stronger cognitive regulation and/or increased co-contraction of trunk musculature.
To investigate LN cellular composition and functional aspects of lymphnodes in pre-clinical patients eventually developing RA compared to patients that do not develop RA, and of lymphnodes of early RA patients compared to non-RA patients, all…
As none of the proposed experimental conditions have been executed with chronic pain patients, our main objective is to determine the sensitivity of the experimental conditions. Besides, we investigate the attention-bias for pain signals that…
This project focuses on detection of predisposing factors (e.g. instability of the joints) for the onset of early CMC-1 joint osteoarthritis based on CMC-1 joint kinematics. For this purpose we need to develop a new diagnostic 4D imaging tool. The…
To test the hypothesis that oral parafunctioning, viz. prolonged gum chewing, has an effect upon the functional symptoms of internal derangements of the temporomandibular joint. To test the hypothesis that the effect of the above-mentioned oral…
Aim of this study is to explore the relation between Th1-cell mediated diseases as psoriasis/psoriatic arthritis and Th2-cell mediated asthma, allergic rhinoconjunctivitis, atopic dermatitis and hand eczema. Question is whether a dysbalans in…
the aim of the proposed study is to assess the load of anatomical hip, knee and ankle joints in people that use one leg prosthesis for sprinting. The loading of both ipsi- (if present) and contralateral joints will be assessed.
The following research questions will be addressed: 1.Is there irreversible joint damage after previous GH excess in long-term cured acromegalic patients?2.What are the clinical characteristics of reported joint problems on clinical examination? 3.…
1. Is EC dysfunction, measured by PWA, present RA patients?2. Is EC dysfunction in RA related to EC activation markers (CRP, thrombomodulin, sVCAM, vWF), AGEs, and the presence of atherosclerosis?3. Is EC dysfunction related to traditional…
The objective of this study is to investigate of inflammatory tissues of patients with SS contain autoreactive B cell expansions that are differently activated compared to other B cell expansions in patients with SS and in persons with salivary…
Objective: to investigate calcium containing crystal release in synovial fluid after exercise as drivers of synovitis in post-traumatic versus non-post traumatic osteoarthritis.
1. to describe NVC findings in patients with pediatric (systemic) auto-immune/-inflammatory diseases:- Juvenile systemic/localized sclerosis (jSSc/lSc)- Childhood-onset systemic lupus erythematosus (cSLE)- Juvenile dermatomyositis (JDM)- Juvenile…
In this study we try to elucidate the possible contribution of inflammation of the joint mucosa to the development of knee osteoarthritis. If we understand more about the inflammatory processes in the synovium that are important in further…