313 results
Hypertension is characterized by vascular remodelling and endothelial dysfunction. Sphingolipids such as ceramide and sphingosine-1-phosphate may play an important role in regulation of vascular contractility and tonus. In this study the altered…
The aim of this study is to investigate if changes in vascular compliance in children with type 1 diabetes are related to endothelial markers and to changes in skin AGE and to investigate whether patients at risk to develop cardiovascular disease…
Pilot study to test the feasibility of measuring glucose uptake in adipose tissue under hyperinsulinemic hypo- ande euglycaemic conditions to quantify the effect of hypoglycaemia on metabolic activity of adipose tissue (VAT, SAT and GFAT) in…
The objective of this study is to investigate whether the differences in DNA methylation between individuals who were exposed in utero to the Dutch Hungerwinter (F1) and their non-exposed, same-sex siblings (F1) - as identified in epigenome-wide…
To investigate the relationship between C3 and vitamin D in adipose tissue and serum in morbidly obese subjects and in subjects who lost weight due to bariatric surgery.
To obtain human fibroblasts from extreme dyslipidemia patients or patients with premature atherosclerosis to study cholesterol metabolism.
Studying the GLP-1 response to a 75 grams oraal glucose load in 10 ZA and 10 WE healthy lean males to see whether GLP-1 is involved in the pathogenesis of T2D in ZA. 1. To investigate whether young lean healthy SA males without a family history of…
The purpose of the current study is to evaluate the difference in TICE in FHBL-patients as compared to unaffected controls, according to the previously developed stable isotope method with minor modifications (METC 10/092). This way we can prove the…
The main objectives of this study is to see if changes in the innate immune system can be found in diseases associated with increased risk for atherosclerosis
The main objective of this study is to measure the effects of the monitoring and feedback tool embedded in a Self-management Support Program on physical activity. The secondary objective is to measure the effect on self-efficacy, quality of life and…
We propose that there will be a link between taste sensitivity and overall metabolic function. We hypothesize that non-tasters, medium-tasters and super-tasters will have different levels of metabolic hormones in their general circulation. Our study…
·To perform clinical studies that assess glucose tolerance in individuals with cancer-predisposing mutations in the CDKN2A gene (p16)(causing familial melanoma)
The aim of this study is to assess differences between lean and morbidly obese subjects in gut permeability, gut microbiota and mucosal inflammation and to assess the effects of weight loss after sleeve gastrectomy on gut permeability, microbiota…
Primary Objective: To determine the local and peripheral immune response in diabetic pregnancies in comparison to healthy controls. Immune response will be measured by counting Th1/Th2-cells, Tregs, NK-cells, monocytes and granulocytes. Produced…
1) Determine whether humanized mice develop enhanced restenosis upon vascular injury after reconstitution with human PBMCs derived from T2DM subjects with or without macrovascular disease.2) Determine what mechanism(s) induces deranged vascular…
We hereby hypothesize that obesity results in an increase in cerebral SERT and DAT, compared to healthy controls. Cerebral SERT and DAT increase will be more prominent in insulin resistant obese subjects compared to obese subjects with normal…
Main objective: 1) To investigate whether BAT activity differs between South Asians and Caucasians.Secondary objectives: 1) To investigate whether sympatic stimulation of BAT differs between South Asians and Caucasians2) To investigate the…
To determine the effect of hypoglycaemia on BAT-activity.
The purpose of this study is to investigate the role of adipokines-secretion in visceral adipose tissue and its influence on the risk for esophageal adenocarcinoma. Examination of adipose tissue may provide important insight into mechanistic links…
To determine whether different circadian rhythms exist between patients with type 2 diabetes and controls in glucose responses, and whether this difference is best detected by either continuous glucose measurement or venous blood sampling. To…