53 results
The main objective of this study is to assess the effect of an acute cardiovascular event on the local and the systemic inflammatory state in humans with AMI as well as the reversibility of these effects after 3 months.
Explore difference in perforating artery pulsatility index between two patients groups with small vessel disease (history of lacunar infarct and deeply located haemorrhage) and healthy controls.
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic RVCL disease carriers, in order to find a *biomarker* for disease stage and progression.
Primary Objective: To assess which measures of microvascular function on 7T MRI are affected in patients with CADASIL, relative to controls.
Area of interest (study setting): Specific aims:Transient triggers and chronic riskfactors (case-crossover and casecontrol)(1) To investigate frequency and strength of association between transient physical andpsychological triggers and early-onset…
The aim of this study is to compare the integrity of the corticospinal tract and cortical reorganization of shoulder girdle muscle representations in chronic stroke patients with and without GHS as well as healthy controls.
To determine the incidence of hypopituitarism in patients after SAHTo identify neurological parameters that predict hypopituitarism after SAHTo determine the value of a Ghrelin test shortly after SAH, to identify subjects with GHD.To determine the…
Primary objective: to assess cortical activity post stroke in a repetitive way to determine cortical involvement in dedicated motor tasks and to relate cortical activity to clinical outcome prospectively after stroke. Secondary objective: to assess…
Measuring the thickness of the microvascular glycocalyx, and make a comparement between lacunar stroke patients and healthy controls.We also compare glycocalyx between patients with and without concomitant silent signs of cSVD on brain MRI.
- To confirm findings in previous studies regarding the loss of functioning motor units in the first day after acute stroke. - To study peripheral nervous system excitability in order to be able to formulate a more detailed hypothesis regarding the…
- To detect carotid and aortic plaque morphology and long term plaque behaviour in patients with cerebral and cardiac end-organ damage (NSTEMI / STEMI and TIA / CVA) with 1.5T MRI-derived virtual histology and relation to biomarkers.- To correlate…
Primary objective: The general aim of this study is to elucidate the role of the glycocalyx in the pathogenesis of DCI in SAH and to study the effects of magnesium on glycocalyx volume.Main objectives of this proposal are:- To assess whether the…
The Primary objective is to quantify the Short Range Stiffness dynamics after stroke in order to quantify the tonic muscle co-activation.
The goal of this project is to gain deeper understanding of the role of lexical connectivity on word finding difficulties in aphasia during recovery in spontaneous speech, through an investigation of age of acquisition, an investigation of the…
The overall aim of this study is to investigate the pathophysiology of ICH by investigating intracerebral hemorrhage in HCHWA-D patients. By investigating triggers for ICH, hematoma expansion, recurrence rate and outcome in HCHWA-D related ICH we…
No studies concerning the relation between energy expenditure and balance control in stroke patients during dynamic conditions are published so far. Therefore, the aims of this study are;(1) To investigate the effect of balance manipulations on…
To sess the relationship between cerebral perfusion and clinical findings (neurological and neuropsychological) in patients with sickle cell disease.To compare iamging fincdings in children with and without sickle cell disease.
To identify novel risk factors for TIA and stroke that can be measured in peripheral blood samples, in particular levels of proteins and other markers and genetic polymorphisms.
Primary researchquestion:1. What are the differences in eye-hand coordination in patients with left or right hemisphere damage compared to healthy age-matched controls?Secondary research questions:2. What is the difference in eye-hand coordination…
Main objective: Contributing to the debate on the necessity of PPC in episodic memory by support of patient data. Secondary objective: Exploring the episodic memory theorem and developing a more sensitive (neuropsychological) research tool usable in…