19 results
To study sensory processing and hyperexcitability in children with ASD and epilepsy using neurophysiological measurements (EEG/ERP).
To establish the incidence and consequences (impairments op body functions, limitations in participation) of traumatic brain injury in children and youth in a region of The Netherlands as well as the incidence of the same symptoms in a group of…
Primary objective of the study:To find out which areas in the brain play a part in the maintenance of tinnitus, and what the roles of those areas are. This will be done using the AEP response in EEG recordings.Secundary objectives of the study:1. To…
The purpose of this research project is to assess whether affected PKD patients have brain abnormalities compared to healthy normal controls. Hypothesis: Paroxysmal kinesigenic dyskinesia affected individuals exhibit abnormal spontaneous activity of…
To set up a repository of genetic material from a large group of well phenotyped people with epilepsy patients to allow the case control association studies, and families for linkage studies, to analyze and detect genetic risk factors for epilepsy.
Primary: To find out which areas in the brain play a part in the maintenance of tinnitus, and what the roles of those areas are. This will be done using BOLD response fMRI imaging.Secondary: 1. To find out which areas in the brain play a part in the…
The present study intends to perform functional magnetic resonance imaging (fMRI) in order to obtain further insight in effects of selective attention on sensory processing. This study aims to compare subjects with normal hearing to patients that…
The current study employs functional magnetic resonance imaging (fMRI) to investigate the auditory and limbic areas in tinnitus patients by means of innovative analysis methods that permit the assessment of functional interactions between brain…
Our overall aim is to obtain a better understanding of brain network damage in dementia patients. We propose a research project with two key objectives:1. Develop improved methods to describe functional brain network damage2. Relate network damage…
Primary:1. Which outcome variables of oculomotor performance and eye-hand coordinatio are useful to distinguish between Dementia with Lewy bodies, Alzheimerdementia and Parkinsondementia.Secundary:1. What are the base line values for the parameters…
The objective of this study is to proof the presence of lesions in the brain of patients with overactive bladder and urge-incontinence (OAB wet) as a central cause of this disorder. This survey is a pilot investigation for a larger study on the…
Primary objective: the primary objective of the present study is to assess whether apathy can be linked to structural brain changes (both atrophy of grey matter, as well as changes in white matter), whether apathy in PD is related to certain…
Our objective is to find predictive biomarkers for disease progression in RVCL-S, a monogenetic small vessel disease, and to dissect disease mechanism to identify new treatment targets to improve health for RVCL-S patients, which may also serve as…
The main objective of the study is to investigate MEG-based hippocampal and whole brain neuronal hyperactivity in preclinical DIAD mutation carriers and to find proof-of-concept for the translatability of findings from preclinical AD mouse models to…
This study aims to relate factors of hypercoagulability, inflammation or general illness itself (all during ICU admission) to microstructural and microvascular abnormalities on follow-up brain advanced 3T and 7T MRI in COVID-19 ICU survivors. By…
To overcome the heterogeneity dilemma that hampers drug development, we propose a translational within-subject approach that integrates clinical, pathological, and molecular/cellular data of induced pluripotent stem cells (iPSC) derived neurons and…
The aim of this research is to study which biological processes precede and can predict loss of brain connectivity in a longitudinal study in 55 individuals with predementia AD, for whom a potential intervention may have maximal effect.This research…
The first aim is to determine an objective acoustic measure to define SMS by comparing acoustic features of probe words to a perceptual score of speech motor movement characteristics and stuttering frequency judged by the expert (i.e., the current…
Primary Objective: The aim of the proposed project is to assess (a) neurocognitive performance and (b) structure and function of brain networks in retired female football players compared to a matched control group of retired female elite athletes…