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To obtain robust evidence for activity-dependent CB and depolarizing CB in CIDP or MMN. This may reveal specific mechanisms of axon loss and provide a rationale for additional treatment aimed at prevention of irreversible axon loss.
To investigate whether propriocepsis or reflexes are present after nerve reconstruction
The objective of this study is to test the hypothesis that in patients with inflammatory neuropathies and conduction blocks, corticosteroid treatment leads to:1. Hyperpolarization and reduced excitability of motor axons. 2. An increase of the number…
To clearify the etiology of CTS and prognostic factors for the development of CTS.
1)To determine the contribution of reversible dysfunction of nerve terminals to weakness 2) To identify electrophysiological patterns that improve classification of GBS patients, and that discriminate between patients with good and poor prognosis 3…
To construct an optimal diagnostic protocol enabling general practitioners to distinguish between dizzy elderly patients who need treatment, dizzy elderly patients who need further diagnostics and dizzy elderly patients who need no further…
Objectives1. Achieve a complete ascertainment of incident CIAP patients in the middle of the Netherlands during a three-year period and determine the frequency of CIAP.2. Establish whether CIAP is associated with the metabolic syndrome, and if so,…
It is therefore planned to study pain perception in peripheral neuropathy in the context of positive and negative emotional stimulation. Although there is a recent plea for the study of emotional modulation of pain, only one study has as yet done so…
To clarify the pathophysiological substrates of residual weakness and fatigue
The aim of the study is to describe the incidence and characteristics of CRPS in the Dutch population. Also will be investigated which factor are associated with the ocurrence of the disease.
1. The objective of this study is to aquire knowledge about the development of reactive hyperaemia and inflammatory responses of the skin after shear- force and pressure loading. We want to investigate if patients with diabetes type 2 will develop…
We purpose to determine whether the international normative values are applicable in our center in 10 healthy participants. Furthermore, CCM will be introduced as additional diagnostic tool in patients with (possible) SFN.
Primary Objective: To study whether nocturnal symptoms of CTS depend on wrist position and, if so, on which position. Identifying which wrist position aggravates CTS could help design a more effective splint. Secondary Objective: To study whether…
To assess the change in excitability parameters induced by IVIG infusion. This will be achieved by comparing excitability-parameters between the time of maximal weakness (just before the next IVIG infusion) and the time of maximal clinical…
The aim is to investigate static and dynamic tissue oxygenation state and skin temperature in patients with CRPS-I and to compare CRPS-I patients with pain patients and healthy controls. The correlation between tissue oxygenation, skin temperature…
We aim to investigate the amount of patients who have lasting benefit from such surgery, and which proportion eventually get recurrent symptoms. We are going to investigate the cohort which has previously been studied by our group (protocol Dr.…
To assess variation in and between a small cohort of ACNES patients and healthy human volunteers.
To assess if resting membrane potential or ion channel activity is abnormal in sensory axons of affected nerves in MMN patients.
1. To study reproducibility of a qualitative scale for abnormality of brachial plexus MRI.2. To study usefulness of quantification of nerve size using maximum intensity projection techniques (MIP) , and compare results with HRUS of the brachial…
1. To explore the complex relation between CRPS, functioning of the HPA-axis and inflammatory activation of the immune system.2. To assess associations between the HPA-axis and psychosocial determinants. 3. To explore the possible role of…