69 results
In the present study we want to examine the effect of salbutamol on the muscle tone of the diaphragm. We also want to examine the correlation between muscle tension measured by EMG and the Clinical Asthma Score. To include the children that come to…
Conditions that promote IL-10 producing B cells in humans are still ill defined. In this project our aim is to investigate the frequnecy of IL-10 producing B cells in healthy volunteers. Next, we aim to compare this to the frequency of IL-10…
To determine the prevalence of mycobacterial, propionibacterial and beryllium, aluminium and zirconium sensitized patients within a well-defined Dutch cohort of biopsy proven sarcoidosis patients.New clinico-pathological phenotypes within the group…
Primary Objective: To prospectively assess the impact and relevance of several risk factors for SAA/acute wheeze that have been identified in retrospective studies, including our own. Secondary Objective: To assess short-term medical and…
Research questions: Primary questions:* Are the new point-of-care instruments for the measurement of VOCs in exhaled breath feasible for use in children and adolescents aged 6 to 20 years?* Are these techniques able to differentiate between healthy…
Main objective: Perform a genome wide association analysis on remission of asthma in a cohort of subjects who were previously diagnosed as having asthma. Secondary objective: Perform genetic association studies between asthma remission and (pathways…
To study in clinically stable COPD patients with muscle atrophy eligible for out-patient pulmonary rehabilitation:1.The short-term effects of 4 months exercise training including nutritional supplementation versus exercise training alone on physical…
This study aims to determine the normal distribution of desmosine in a healthy population and a population of patients with COPD (ranging from GOLD I-IV). In addition, the inter-day variation and the correlation with 24-hour urinary desmosine will…
Primary objective:Test whether preservation of upper limb compared to lower limb muscle function is associated with preservation of functional arm use compared to functional leg use in daily life in patients with COPD compared to healthy controls.…
What is the correlation between change in % fall in FEV1 (*FEV1) after an exercise challenge 20h after a single dose of montelukast and after 4 weeks of treatment with montelukast?
Quantify how many frail elderly aged over 65 years with reduced exercise tolerance and/or exercise induced dyspnoea have previously unrecognised COPD and heart failure.Quantify the difference in prevalence of unrecognised COPD and heart failure…
We hypothesize that ER stress contributes to epithelial dysfunction in Z-AATD, resulting in enhanced inflammation. In addition, we hypothesize that the airways of Z-AATD patients are particularly prone to bacterial infection and colonization through…
Primary objectives:-Compare the stride-interval correlations (α) of gait in COPD patients with healthy age matched adults using accelerometers.-Investigate if this information is clinically useful to distinguish between GOLD stages 1+2 / 3 / 4.…
The objective of the present study is to investigate the user satisfaction, clinical effectiveness, and economic outcomes of the computer supported exercise program.
The main objective of this study is to assess more thoroughly the differences in gait patterns between COPD patients and healthy controls. Other objectives are to assess differences in gait patterns between GOLD stages and two age groups in healthy…
The overall aim of the project is to define effects of genetic and non-genetic variants on pharmacological treatment response in children with asthma. The following questions will be answered:- What are the characteristics of children who do not…
Present and evaluate a novel monitoring system for 24/7 continuously monitoring of COPD patients, using cHealth technologies.
Objective: To compare platelet reactivity and formation of platelet-monocyte complexes between patients with COPD and age-matched controls and to relate this to systemic inflammation.
The study objectives are to measure the impact of swimming in chlorinated water on the upper and lower airways of children with and without *doctors diagnosed asthma* by means of the following methods: 1.Tympanometry after otoscopy 2.Airway…
To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.