28 results
To determine the prevalence of mycobacterial, propionibacterial and beryllium, aluminium and zirconium sensitized patients within a well-defined Dutch cohort of biopsy proven sarcoidosis patients.New clinico-pathological phenotypes within the group…
Main objective: Perform a genome wide association analysis on remission of asthma in a cohort of subjects who were previously diagnosed as having asthma. Secondary objective: Perform genetic association studies between asthma remission and (pathways…
This study aims to determine the normal distribution of desmosine in a healthy population and a population of patients with COPD (ranging from GOLD I-IV). In addition, the inter-day variation and the correlation with 24-hour urinary desmosine will…
We hypothesize that ER stress contributes to epithelial dysfunction in Z-AATD, resulting in enhanced inflammation. In addition, we hypothesize that the airways of Z-AATD patients are particularly prone to bacterial infection and colonization through…
Primary objectives:-Compare the stride-interval correlations (α) of gait in COPD patients with healthy age matched adults using accelerometers.-Investigate if this information is clinically useful to distinguish between GOLD stages 1+2 / 3 / 4.…
Objective: To compare platelet reactivity and formation of platelet-monocyte complexes between patients with COPD and age-matched controls and to relate this to systemic inflammation.
The study objectives are to measure the impact of swimming in chlorinated water on the upper and lower airways of children with and without *doctors diagnosed asthma* by means of the following methods: 1.Tympanometry after otoscopy 2.Airway…
To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.
With this project we aim to clarify the differences in airway pathophysiology between asthmatics and healthy controls that underlie the prolonged survival of virus and the exaggerated inflammation in virus-induced exacerbations of asthma. We will…
To investigate the role of different ADAMs (e.g. ADAM10 and ADAM17) in cigarette smoke extract (CSE)-induced production of inflammatory parameters (TGF-* shedding, MUC5AC and IL-8) in primary epithelial cells and compare the effects in cells derived…
To compare the levels of vitamin D in subjects with non-atopic asthma to those in subjects with atopic asthma and those in healthy non-atopic subjects
The overall aim of the study is to identify the role of indoor biological and chemical agents that lead to respiratory, inflammatory and allergic health impacts in school aged children. The focus is on microbial exposures due to dampness problems of…
The aim of the study is first to develop knowledge concerning underlying mechanisms that can explain the relationship between obesity and asthma.
To investigate the presence and extent of small airways disease in subjects with asymptomatic AHR, patients with asthma and non-AHR controls. Specific research questions:1) Do subjects with asymptomatic AHR have less small airways disease than…
Main objective: To investigate differential gene-expression in nasal epithelium of asthmatics in complete remission, in clinical remission, not in remission and healthy controls.
Is there an association between involvement in incidents with airway irritants and respiratory effects in first responders.
In the present project we aim to characterize the lung CD8+ T cell immune system and analyse if differences exist between *healthy* smokers and COPD patients. If so, these data will help to clarify the (immuno)pathogenesis of COPD. Specifically, we…
Determination of possible risk factors for developing osteoporosis in GOLD II COPD patients.
The primary goal of this research is to characterize the regulatory Treg population in peripheral blood and bronchoalveolar lavage in patients with sarcoidosis compared to healthy controls. What is the frequency of these cells, what is the phenetype…
Hypothesis:In auto-immune hyperthyroidism there is an increase of (eosinophil)airwayinflammation compared to healthy test subjects.Objective:testing our hypothesis by answering the following questions:1. What is the difference in NO in exhaled air…