119 results
This study aims at, first, assessing the most relevant exposure aspects of night-shift work and, second, identifying biomarkers for both acute and chronic circadian disruption associated to these specific nightshift work aspects. By applying…
We aim to gain insight into the incidence and severity of CIPN and its influence on patient-reported outcomes (i.e. health related quality of life (HRQoL), disease-specific complaints, depression, fatigue, sleep problems) among a prospective…
The objective of the study is to determine the protein profile of cerebrospinal fluid of non-pregnant women using mass-spectrometry.This study is a follow-up project on the previously performed study (LEPRA, CSF and pre-eclampsia, MEC 2007-087). In…
1. Immunology and Pathology:To determine the immune response of patients with simple and complex appendicitis in order to identify markers which distinguish between simple and complex appendicitis.2.Clinical and Imaging:To analyze the differences in…
To investigate the underpinnings of ADHD and its persistence into adulthood: Through studying genetic factors, in combination with genomic, microbiome, cell-based, neuroimaging, neuropsychological and psychiatric assessment we aim to gain more…
The primary objective of the current study is to (further) investigate the role of reward and punishment sensitivity in Anorexia Nervosa and obesity by examining general and disorder-specific appetitive and aversive biases. The secondary objective…
The main aim of the proposal is to study the processes involved in non-chronic vs. chronic drug seeking behavior in samples of alcohol dependent persons (ADs) and pathological gamblers (PGs) with different levels of chronicity. We thereby rely on…
To determine if a marked change in the concentrations of one or more of the selected biomarker is evident before PUs are visible
The main objective of this study is to assess the effect of an acute cardiovascular event on the local and the systemic inflammatory state in humans with AMI as well as the reversibility of these effects after 3 months.
Primary Objectives:- Determine the effect of pulmonary vasodilatation on indexed cardiac output during simulated exercise.- Characterization of structural properties of small pulmonary arteries.Secondary Objectives: - Investigate the effect of…
Explore difference in perforating artery pulsatility index between two patients groups with small vessel disease (history of lacunar infarct and deeply located haemorrhage) and healthy controls.
To study sensory processing and hyperexcitability in children with ASD and epilepsy using neurophysiological measurements (EEG/ERP).
The primary objective will be the prevalence of medial arterial calcification, defined as an ABI * 1.3 and a TBI > 0.7, among hemophiliacs compared with non- hemophiliacs matched by sex and age.
In this study, the following questions will be answered:1. Does larval therapy accelerate wound healing?2. Do single larval secretions accelerate wound healing?3. Is the bacterial load in the wound reduced during larval therapy or is the microbiome…
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic RVCL disease carriers, in order to find a *biomarker* for disease stage and progression.
The aim of this study is to identify Galectin-1 and -3 as possible biomarkers in capsular contracture. Moreover, we plan to investigate whether HLA-typing and IgE levels in subjects can be used to predict the chance of development of capsular…
1. To investigate a possible increase intimal-media thickness (IMT) is found of the iliacal artery in endofibrosis2. To investigate a possible altered distention is found of the iliacal artery in endofibrosis3. To compare IMT and distention…
To investigate the origin of BA we will assess which TLR(s) is/are activated. To test the hypothesis that during development of BA and associated liver fibrosis there is a *leaky gut* and/or a change in microbiome we will use human material to…
1) To investigate IFN type I signature as an early biomarker for progression to SLE. 2) To establish effects of increased innate immune system activation on adaptive immune system, in particular on B-cells. 3) To establish IFN type I activation as…
The primary objective of this study is to evaluate whether there is an increased binding potential of the TSPO ligand [11C]PK11195, which is a marker for microglia activation in neuroinflammation, using PET in patients with CFS compared to healthy…