41 results
To explore cardiovascular remodelling with subsequent altered cardiac function (assessed as strain rate) in extremely premature neonates (born <30 weeks and/or birth weight < 1000 gram) with FGR.
The objectives of this study are: 1. to identify new genetic variants causing or predisposing to PD; 2. to characterize the clinical phenotype in PD associated to specific genetic variants; 3. to investigate the molecular mechanisms of PD in…
Primary objective: To assess the effect of ICI on progression of coronary non-calcified plaque volume and ICI-related cardiovascular events by measuring differences in plaque burden using repeated CCTA.Secondary objectives:- To evaluate the relation…
The aim of this study is to investigate to what extent biomarkers are related to the development of ventricular arrhythmias, in order to improve the indication for ICD therapy.
The main objective is to quantify neuroinflammation using [11C]SMW139 PET-scans in subjects along the AD continuum and age/sex-matched cognitively unimpaired subjects.
The primary objective is to explore the urine microbiome (urobiome) composition of postmenopausal women with and without RUTI at five scheduled time points during one year of follow-up, as well as before, during, and after UTI episodes when they…
The aim of this study is to better understand the role of mammary lactation physiology and breast composition in regulating breast milk transfer during milk extraction. The secondary aim is to validate the performance of diffuse optical…
Objective: The aim of the present study is to study the effect of increased adrenaline levels on the inflammatory response (e.g. leukocyte phenotype, cytokines, inflammatory proteins) by administering exogenous adrenaline. Secondary aims consist of…
The primary objective of the current study is to investigate whether self-disgust is heightened in patients with AN. If this indeed is the case, this would provide important leads to improve existing treatment options for AN.
In this study, we therefore aim to investigate how trained immunity is systemically regulated in ANCA vasculitis patients and how the degree of trained immunity affects disease activity and severity. A better understanding of these processes…
The aim is to investigate changes in nocturnal and postprandial glucose and glycogen metabolism in individuals with IFG and IGT when compared to healthy, non-diabetic, overweight participants. In addition, it will be investigated if reducing…
Primary objectives:To evaluate the pathogen host interactions between S. aureus and NS patients:o IgG and IgG4 responses against S. aureus antigens in NS patients will be compared with IgG and IgG4 responses against antigens of other bacteria (e.g.…
Main objectives: 1. Determine whether the POAG patients with low values of the blood mtDNA copy number have a low mtDNA copy number and low mitochondrial function in skin fibroblasts, using in vitro assays of mitochondrial function.2. Explore the…
Identification, segregation analysis, and functional characterization of genetic variants possibly causing rare bleeding disorders. The following questions will be answered:1) Can we identify (new) causal variants that explain the phenotype of…
To identify causal socio-genetics longevity mechanisms protecting from (multi)morbidity in humans:1. The primary objective is to disentangle novel rare-, and structural gene variants that can explain longevity and protection from (multi)morbidity in…
The primary objective of this study is to investigate how the vascular regulation is altered in the maternal as well as placental vasculature of women with pregnancy disorders (preeclampsia, pregnancy-induced hypertension, FGR, preterm birth,…
To assess kidney oxygenation in obese, hyperfiltering adults with T2D before and after bariatric surgery for men and women separately determined by BOLD-MRI
The main aim is to study early neurocognitive functioning and development in very young children with SCD. The secondary aims are to identify determinants (risk and protective factors) and biomarkers of early neurocognitive deficits in SCD and to…
(also see: C1. Protocol, page 9, paragraph 2)Primary: Creating a metabolic bio-database with body material of patients with inherited metabolic diseases, combined with clinical data.Secondary: Achieve better participation in national and…
Primary: - Examine longitudinal developmental trajectories of structural and functional brain metrics in relation to genetic, clinical, psychological, environmental, and cognitive information in familial high-risk offspring and control children (…