60 results
The aim of this study is to investigate the effect of guided tapering in early pregnancy as compared to continuation of SSRIs during pregnancy. We will study effects on both mother and child with a pragmatic approach.
To investigate the feasibility and utility of indocyanine green fluorescence imaging for intraoperative perfusion assessment in patients undergoing gastro-intestinal surgery, primarily measured by the number of intraoperative changes in operation…
To elucidate the molecular mechanisms underlying renal disease that lead to chronic kidney disease. To validate pathogenic variations in functional in vivo models.
Primary Objectives: 1. To assess the values of ARI and APDR in NICM patients. 2. To assess the three-dimensional heterogeneity of ARI and APDR in NICM patients.3. To compare 1. and 2. with the same data collected from non-NICM patients.4. To…
Health outcomes for people at risk of or suffering from non-communicable lung diseases in low-resource settings will be improved by developing capacity for implementation of evidence-based interventions for prevention, diagnosis and treatment in…
For the prevention of diabetic foot ulceration, evidence exists to support the use of home-monitoring of foot skin temperature by means of a hand-held infrared skin thermometer. However, the construct validity of skin temperature measurements is…
Primary Objective: to investigate whether the variation of the number of lumbar vertebrae in humans is coded by the same genes which are responsible for this as well as in other mammals.
To determine the variability of cognitive features in NF1 and TSC in the absence of genetic variability.
Cognition in patients with Juvenile Myoclonus Epilepsy and their first degree healthy family members
Key Question: What is the level of cognitive performance in healthy siblings of juvenile myoclonic epilepsy patients compared to that of patients with juvenile myoclonic epilepsy?
To identify biomarkers associated with OSA in bariatric surgery patients prior to surgery; to investigate the effect of bariatric surgery on these with OSA associated biomarkers; to identify biomarkers that predict amelioration of OSA after…
Primary Objective: To study whether nocturnal symptoms of CTS depend on wrist position and, if so, on which position. Identifying which wrist position aggravates CTS could help design a more effective splint. Secondary Objective: To study whether…
We aim to recognise potential genetic modifiers for mutations in PMS2. This will be approached through comparing a selection of CRC-related genes in the exome of members of a PMS2 family who differ in age of onset and severity of disease.
This monocenter randomized controlled trial aims to compare postoperative outcomes of a laparoscopic valvuloplasty with a Toupet fundoplication in patients with GERD with a maximum hiatal hernia of 3cm. In addition, an economic evaluation of the new…
(also see: C1. Protocol, page 12, paragraph 2)Primary Objective:Improving risk assessment of acute porphyric attacks and complications in patients with acute porphyria.Secondary Objectives: 1. Obtain and describe basic demographics and statistics,…
Primary Objectives: 1. Determine novel pathogenic gene mutations in families with congenital upper limb anomalies by whole genome sequencing;2. Determine the contribution of these genes in embryonic development, including proliferation and cell…
The aim of this study is to investigate the structure and the biological behaviour of the peritoneum, in relation to the specific growth of EOC on the peritoneum, in order to identify the component of the peritoneum that maintains the blood-belly-…
The major goal of this study is to develop a systematic and stepwise approach for dry eyes. First, it will be evaluated whether Tes glasses are a diagnostic tool for dry eye diseases. Second, it will be evaluated or it can make a distinction between…
Investigate whether differences of the thermostat set point between the sexes might be responsible for BAT differences between men and women. Secondly, we investigate whether women have a different glucose uptake during cold exposure than men.
The primary objective of this study is to compare muscle blood flow and oxygen consumption, as measured by NIRS, in patients with cold type CRPS and healthy controls. The secondary objectives of this study are to compare muscle oxygenation (tissue…
Sentinel node mapping for bladder cancer is possible using the hybrid tracer ICG-99mTc-nanocolloid