22 results
The study consists of two parts.Objective 1 to document the day by day changes of tinnitus that participants with intermittent tinnitus experience. This objective is aimed for in part 1 of the study. In addition, this part allows the selection of a…
Primary ObjectivesThe primary objectives are to evaluate in infants who are hospitalized with RSV infection:• the pharmacokinetics of JNJ-53718678 after multiple oral doses;• the safety and tolerability of JNJ-53718678 when administered for 7 days.…
Verification of functional tests with the LoRRca, a next generation ektacytometer, on red blood cells of healthy individuals with or without comorbidities/risk factors.
Although DC vaccinations have been used in allo-HCT settings, no previous studies have been performed using a CBDC vaccine after CBT. This study will therefore be subdivided into 2 parts:- Part A: to determine a safe dose of the vaccination, and -…
A primary goal is to relate EEG based rsFC to changes in excitability of the brain. Since the excitability recorded with the MEPs reflect antiepileptic drug effects [1,2] it is assumed that these changes will be more pronounced after withdrawal of…
The main objective of this study is to evaluate whether our protocol results in non-functional overreaching in athletes in a controlled and safe way
To investigate FGF19 signalling and metabolic and functional consequences of a disturbed enterohepatic cycle in patients with obstructive cholestasis
The primary objective of this study is to explore the PSA response rate to cabazitaxel in mCRPC patients who have progressed to docetaxel and to correlate the PSA response to AR-V7 expression in CTCs. Exploratory objectives include documenting the…
The first aim of this study is to examine differences in implicit and explicit learning in children born very preterm. The second aim is to test the alleged role of working memory and attention on (explicit) motor skill learning in preterm children…
Primary objective:To determine the most optimal technique and timing of surgery for correction of peri-orbital osseous deformities (hypertelorism, vertical orbital dystopia, and/or midface hypoplasia) for each specific condition (1. syndromic…
Present and evaluate a novel monitoring system for 24/7 continuously monitoring of COPD patients, using cHealth technologies.
Primary Objectives:1. To compare protein synthesis rate of the tumour and normal pancreas between cachectic and non-cachectic patients with pancreatic cancer.Secondary Objective(s):1. To compare protein synthesis rate of liver, intestinal, adipose…
Primary Objective: To determine if spinal and cortical balance control mechanisms mediate the age-associated decline in balance skills. Secondary Objective: To determine the reliability of TMS and H-reflex measures in the soleus muscle in different…
The objective is to investigate the correlation between bacterial/viral gut infections and acute appendicitis in children.
To assess arterial wall inflammation, measured with 18F-FDG PET/CT scan, in patients with intermediate and severe FH phenotype, as well as the change in arterial wall inflammation following PCSK9 inhibition.
The aim of the proposed study is to investigate the presence of dopaminergic abnormalities in relation to apathy in persons with a high risk for psychosis. Second, we intend to explore the relation between the dopamine system and apathy in general,…
Primary Objectives:The primary objectives are to evaluate in infants who are hospitalized with RSV infection:- the pharmacokinetics of JNJ-53718678 after multiple oral doses;- the safety and tolerability of JNJ-53718678 when administered for 7 days.…
Both two transition management interventions will be effective in the reduction of the school transition problems of children with ASP. We have no hypothesis about which intervention will be most effective in the reduction of childhood…
Our aim is to test whether disrupting the process of fear memory reconsolidation is an effective as well as efficient intervention for patients with panic disorder. A secondary aim is to test whether the expected reduction in panic attacks and…
Assessing different modalities of ektacytometry in diagnosing thalassemia and/or iron disorders. Investigating the influence of hemoglobinopathies and iron disorders on red cell membrane deformability in comoparison with healthy controls.