23 results
Smell and taste function change during chemotherapy consequently affecting 1) dietary intake 2) eating behavior 3) anthropometry 4) quality of life
We aim to prevent or reverse developmental regression in patients with Kleefstra syndrome. We hypothesise that the regression we observed is the result of a psychotic disorder, which isnot properly recognised by clinicians and often not treated…
The main objective of our Center for Translational Pediatric Pulmonology (CTPP) is to establish models of bronchial epithelial function in children, by (1) epithelial organoid cultures derived from bronchial epithelial cells; (2) bronchial brushings…
The primary objective of this study is to measure the effectiveness of the TFT for URMs living in the Netherlands. The research question is as follows: is this TFT effective in decreasing symptoms of posttraumatic stress and depression in URMs…
Main objectives are:1. To explore differences in cerebral perfusion and flow pulsatility between CoA patients and controls.2. To quantify ischemic white matter lesions and cerebral microbleeds in CoA patients with comparison to controls.Secondary…
Our research aims to establish informative tools in the laboratory for studying the molecular and cellular pathways that are altered in SETBP1 disorder.
Primary objectives* To correlate social, physical, and biometric activity of FSHD patients with the FSHD Clinical Score (Lamperti) and the Timed Up-and-Go Test.* To evaluate the feasibility and subjective burden of remote monitoring in FSHD patients…
To study the effects of 2 standard treatment timing strategies for glucocorticoid dosage on androgen concentration in CAH children: a. highest dosage in the morning, b. highest dosage in the evening.
To investigate the role of talkers* voices in speech communication in NH, HI, and CI children and adult listeners, and how the perception of talker voice information relates to the processing of indexical and linguistic information among these…
Primary objective: The primary objective of this study is to assess the effectiveness and cost-effectiveness of the Transmural Trauma Care Model (TTCM) as compared to usual care.The research question addressed is:Is the Transmural Trauma Care Model…
To investigate neural response patterns to visually and orally presented palatable (high vs low caloric) and unpalatable (high vs low caloric) foods in AN patients and matched healthy controls (HC). This will be investigated through 1 study with 2…
Specific Aims: In children with severe PARDS:1. To compare the effects of prone positioning with supine positioning on ventilator-free days.2. To compare the effects of HFOV with CMV on ventilator-free days.Hypothesis: Children with severe PARDS…
The main goal of this study is to test the feasibility of two different operant conditioning methods to decrease hyperreflexia of children with CP/SP/HSP, using real-time visual feedback.
The primary objective of the study is to develop new sensitive and quantitative outcome measures for clinical trials in ALD. The secondary objective is to identify biomarkers to stratify patients based on disease progression rate.
Primary objective; To asses the accuracy and precision, the criterion validity of the app compared to the goniometer and the inter and intra observer reliability Secondary objective; To evaluate the applicability of the PROSUP mobile phone…
1) To study cognition in children with absence epilepsy and the development of functional brain organization.2) To find prognostic factors in terms of clinical, 24h-video-EEG or/and MRI characteristics for cognitive deterioration and/or poor seizure…
The current study has two main objectives:- To investigate if the effectiveness of CsA differs for NMF low vs. NMF normal (corresponding with FLG mutation vs. FLG wild type) in children with moderate-to-severe AD. - To investigate if the…
Primary objective1. The primary aim of the study is to answer the question whether specification of a positive direct antiglobulin test and/or red blood cell autoantibody specification is correlated with the clinical course in patients with AIHA. We…
Primary objectiveTo evaluate current clinical practice and develop a population based Campath® (Alemtuzumab) pharmacokinetics model for predicting total Alemtuzumab exposure after i.v. administration before allogeneic stem cell transplantation in…
We aim to quantify the contribution of individual HSCs to blood (re-)generation in pediatric HSCT recipients and their donors, and to unravel the consequences of transplantation on HSC long-term genomic integrity.