149 results
In the proposed study, we conduct a randomized controlled trial to evaluate the (cost-)effectiveness of ABFT compared to Treatment As Usual (TAU) on suicidality, as delivered in daily practice. We hypothesize that, compared to TAU, ABFT will lead to…
To measure offset analgesia in surgical patients before and after they received
This study has been transitioned to CTIS with ID 2024-510919-29-00 check the CTIS register for the current data. OBJECTIVES - Phase 2 (not to be conducted in NL):Phase 2 Primary Objective:- Identify a setrusumab dosing strategy in subjects with OI…
Primary objective (after 1 year)- To evaluate the effectiveness of the nurse-led GILL eHealth intervention in patients with serious mental illnessSecundary objectives (after 1 year)- Improve metabolic syndrome severity- Improve fitness, physical…
To assess the effect of a bundle of non-pharmacological interventions implemented in the post-anesthesia care unit on the total serum cortisol levels after intermediate and major surgery.
The primary objective of the cohort study is to test the effectiveness of a complex intervention of paediatric sleep problems on a 24-hour sleep duration (day- and nighttime) of children aged 6-36 months of age with sleep onset and/ or sleep…
Primary Objective: Investigate the difference in composite endpoint MACE, major amputation, or target vessel revascularization in PAD Fontaine II patients with and without antiplatelet resistance as measured by a. VerifyNow b. Genetic testing of…
The main objective of this study is to improve surgical and oncological outcomes for patients with right-sided colon cancer by conducting a prospective sequential interventional cohort study that aims to evaluate national implementation of the LRHC…
This study has been transitioned to CTIS with ID 2024-518890-33-00 check the CTIS register for the current data. To determine if clopidogrel treatment can be optimized in patients with a low or high BW/BMI compared to patients with a normal BW by…
This study has been transitioned to CTIS with ID 2024-515893-29-01 check the CTIS register for the current data. To study whether ziltivekimab therapy reduces arterial wall inflammation as assessed by imaging, and reduces the systemic inflammatory…
Assessment and quantification of the function of the external anal sphincter by means of 4D ultrasound.
Objectives: Primary: to determine whether SRT reduces the seizure frequency resulting in a reduction of at least 75% (RAEC I-III) in patients with drug-resistant focal epilepsy when compared to standard of care. Secondary: Assess quality of life (…
The aim of the present study is identifying CEBA profiles in pwMS and subsequently developing a feasible screening tool allowing quick identification of CEBA profile and subjective burden of pwMS in clinical practice, providing a suitable indication…
The aim of this study is to identify whether the availability of a PSD for military veterans with PTSD coincides with clinically significant changes in wellbeing, behaviour and functioning in veterans and their families compared to veterans with…
Primary objectives: - To examine how environmental exposures influence the prevalence, 5-year incidence and progression of cardiometabolic and chronic respiratory disease in the general population. - To determine the mediation effect of lifestyle…
Primary Objective: To assess AET*s effectiveness concerning eating disorder symptoms, autonomy-connectedness (primary outcome measures), general psychopathology, self-esteem and quality of life (secondary outcome measures). Secondary Objective(s):…
To overcome the heterogeneity dilemma that hampers drug development, we propose a translational within-subject approach that integrates clinical, pathological, and molecular/cellular data of induced pluripotent stem cells (iPSC) derived neurons and…
This study is aimed at understanding status and future cardiovascular disease (CVD) risk in UC outpatients in remission undergoing different anti-inflammatory therapeutic regimens (tofacitinib (a JAK1 - inhibitor), anti-TNF (infliximab or adalimumab…
The overall objective of the PRESTO-2 study is to evaluate the implementation of the Stroke Triage App, a decision support tool for individualized prehospital triage of patients with potential stroke.The specific objectives are the following:1)…
This study aims to demonstrate superiority of the research intervention (over standard of care) in [1] surgical success and [2] cost-effectiveness and non-inferiority in morbidity