309 results
The main point of this study is to detect in a controlled fashion if there is a relationship between CCSVI and MS. We focus on 5 parameters indicative of CCSVI: 1-reflux in the internal jugular vein (IJV) or in the vertebral vein (VV), or both with…
W want to investigate the influence of a mutaion in the MH allel on the HPV and the normal reaction of MH patients to hypoxia
PrimaryTo investigate the inter-rater and intra-rater variability of a novel neurophysiological measurement (Motor Unit Number Index, MUNIX) for estimation of functioning motor units, in healthy controls and ALS patientsSecondaryTo evaluate the…
To fully characterize skeletal muscle strength and endurance, phenotype and muscle fiber type-specific satellite cell content in frail elderly as compared to those elderly that do not classify as frail according to clinical criteria.
To evaluate exhaled breath sampling approaches and their impact on results quality. To establish if sampling procedures impact specificity and sensitivity in extracting information of interest * in our case impact of garlic/fish oil supplements on…
To compare the accuracy of syndesmotic reduction on an axial CT-scan postoperatively (reflecting syndesmotic malreduction) after anatomical open reduction and fixation of the posterior malleolar fragment versus no fixation of the posterior fragment…
The primary goals of this study are to: i. Identify genetic variations responsible for PLP across the whole genomeMore than 90% of SNPs are found in introns or intergenic regions and most of them are probably of little functional consequence.…
To determine and compare PK profiles of two of the most used ROOs in cancer patients: one intranasal fentanyl formulation (INFC, Instanyl®) and one sublingual fentanyl formulation (SLF, Abstral®).
We hypothesize that verapamil reduces progression from paroxysmal to persistent AF, improves rate control, exercise tolerance and quality of life and reduces costs compared to metoprolol.
Currently, a 5-point mask and a standard headrest is used in the H&N patients. By replacing the standard headrest for an individual headrest that includes both the head, neck and part of the shoulders, it is expected that the translations…
Although DC vaccinations have been used in allo-HCT settings, no previous studies have been performed using a CBDC vaccine after CBT. This study will therefore be subdivided into 2 parts:- Part A: to determine a safe dose of the vaccination, and -…
Verification of functional tests with the LoRRca, a next generation ektacytometer, on red blood cells of healthy individuals with or without comorbidities/risk factors.
A primary goal is to relate EEG based rsFC to changes in excitability of the brain. Since the excitability recorded with the MEPs reflect antiepileptic drug effects [1,2] it is assumed that these changes will be more pronounced after withdrawal of…
The main objective of this study is to evaluate whether our protocol results in non-functional overreaching in athletes in a controlled and safe way
The aim of our project is to perform a novel mass screening to detect CD in 12 months-4 years old children who visit the YHCCs in a well-described region in the Netherlands, to show that it is feasible, efficient, cost-effective and well accepted by…
The primary objective of this study is to explore the PSA response rate to cabazitaxel in mCRPC patients who have progressed to docetaxel and to correlate the PSA response to AR-V7 expression in CTCs. Exploratory objectives include documenting the…
Primary Objective: To assess the hemodynamical effects of administration of AS in FGR fetuses and to compare these effects with those that occur in appropriate for gestational age (AGA) fetuses. Secondary Objective(s): To investigate the effect of…
To investigate FGF19 signalling and metabolic and functional consequences of a disturbed enterohepatic cycle in patients with obstructive cholestasis
Primary Objectives:1. To compare protein synthesis rate of the tumour and normal pancreas between cachectic and non-cachectic patients with pancreatic cancer.Secondary Objective(s):1. To compare protein synthesis rate of liver, intestinal, adipose…
In order to confirm previous observations and to increase our understanding of the patho-physiologic mechanism of the plasma lipid changes; in this study, we will prospectively measure the blood lipid profile of approx. 120 malaria patients and an…