1706 results
The present research proposal aims at investigating the distinction between healthy and pathological narcissism. In particular, the role of empathy is studied.The present study is the first in which patients with narcissistic personality disorder…
The primary goals of this study are to: i. Identify genetic variations responsible for PLP across the whole genomeMore than 90% of SNPs are found in introns or intergenic regions and most of them are probably of little functional consequence.…
Objectives1.3.1 Primary ObjectiveCompare the efficacy of BMS-945429 versus placebo for induction of clinical remission (defined by an absolute Crohn*s Disease Activity Index [CDAI] score < 150) at Week 8 (IP-57).1.3.2 Secondary Objectives•…
To determine whether the attenuated salivary cortisol response in children with asthma can be explained by the maintenance use of inhaled cortiocosteroids, the chronic inflammatory disease, or the attenuated exercise capacity.
The general goal of our study is to unravel the anatomical and functional correlates of tinnitus in the human brain using structural and functional magnetic resonance imaging (MRI). We will use a high-field (7 T) MRI scanner and obtain a) detailed…
The primary objective is to evaluate the efficacy of orally administered cebranopadol in comparison with morphine sulfate PR in subjects suffering from chronic moderate to severe pain related to cancer.The secondary objective is to compare the…
The objectives of this study is to determine the recovery and survival of platelet concentrates; in the first phase, a comparison will be made for platelet concentrates in plasma stored for 2-3 days versus those stored for 6-7 days; in the second…
The primary objective is to evaluate possible clinical effects correlated with α3β1 and CD151 expression in human epidermal malignancies, and relate these findings to the effects of α3β1 and CD151 deficiencies in skin cancer in the mouse.…
The aim of this study is to investigate the effect of guided tapering in early pregnancy as compared to continuation of SSRIs during pregnancy. We will study effects on both mother and child with a pragmatic approach.
In this study, the following questions will be answered:1. Does larval therapy accelerate wound healing?2. Do single larval secretions accelerate wound healing?3. Is the bacterial load in the wound reduced during larval therapy or is the microbiome…
To further characterize the transport of phenylalanine and other large neutral amino acids across the blood-brain barrier in PKU patients with high and low brain vulnerability to elevated blood phenylalanine concentrations, we will investigate…
In order to confirm previous observations and to increase our understanding of the patho-physiologic mechanism of the plasma lipid changes; in this study, we will prospectively measure the blood lipid profile of approx. 120 malaria patients and an…
The primary objective of this study is to compare respiratory muscle strength values obtained using volitional techniques with values obtained using non-volitional techniques. The secondary objective is to compare the change for these two sets of…
The study consists of two parts.Objective 1 to document the day by day changes of tinnitus that participants with intermittent tinnitus experience. This objective is aimed for in part 1 of the study. In addition, this part allows the selection of a…
Primary ObjectivesThe primary objectives are to evaluate in infants who are hospitalized with RSV infection:• the pharmacokinetics of JNJ-53718678 after multiple oral doses;• the safety and tolerability of JNJ-53718678 when administered for 7 days.…
Verification of functional tests with the LoRRca, a next generation ektacytometer, on red blood cells of healthy individuals with or without comorbidities/risk factors.
We here wish to apply new advancements in multi-color flow cytometry for a detailed and sensitive examination of mast cells in peripheral blood of patients with SM.
Although DC vaccinations have been used in allo-HCT settings, no previous studies have been performed using a CBDC vaccine after CBT. This study will therefore be subdivided into 2 parts:- Part A: to determine a safe dose of the vaccination, and -…
To investigate the feasibility and utility of indocyanine green fluorescence imaging for intraoperative perfusion assessment in patients undergoing gastro-intestinal surgery, primarily measured by the number of intraoperative changes in operation…
A primary goal is to relate EEG based rsFC to changes in excitability of the brain. Since the excitability recorded with the MEPs reflect antiepileptic drug effects [1,2] it is assumed that these changes will be more pronounced after withdrawal of…