2094 results
To study the role of brain metabolites and macromolecules in relationship to pathogenesis, structural brain changes and clinical phenotype of ALS. This will reveal underlying molecular mechanisms of pathogenesis, structural brain changes and…
Our primary objective is to investigate the effects of methylphenidate on language comprehension and creativity, and to link these effects with the effects of methylphenidate on working memory. Our secondary objective is to establish the relation…
Primary objective of this study is to assess the reliability and validity of the neuromuscular parameters of ankle joint impedance estimated by nonlinear SIPE technology in children with CP compared to current clinical manual tests and gait analysis…
To characterize phenotypical parameters, cytokine production and epigenetic characteristics of monocytes in patients with diabetes mellitus type 2, stratified according to antidiabetic treatment regime. Ex vivo exploration of the conditions which…
Primary Objective: To assess whether both OCT (optical coherence tomography) and/or HSI (hyperspectral imaging) detect differences in glioma tissue as compared to healthy tissue as examined during brain-surgery.Secondary Objective(s): To assess if…
2.1 Primary objectives2.1.1 Cross-sectional part• Technical evaluation of the functional and structural outcome measures to support a biomarker qualification by regulatory authorities and payers. 2.1.2 Longitudinal part • Assessment of prognostic…
In this proof-of-concept study, we aim to characterize healthy individuals with regard to their individually predominant neural mechanism. Thereby, we aim to divide a sample of healthy individuals into three clusters based on their individual…
Here we will generate iPS cells from patients with genetic neurodevelopmental disorders and (related) healthy control individuals, that can be used to generate in vitro disease models to further study the mechanisms behind these disorders.
1. To investigate the influence of different immunosuppressive drugs on the immune response of placental derived mononuclear cells, peripheral blood derived mononuclear cells, and cord blood derived mononuclear cells.2. To investigate the neonatal…
To investigate whether enhanced expression of growth factor receptors (FGF-R, PDGF-R and VEGF-R) and increasedvascular cell proliferation in the lung of IPF or PAH patients can be assessed using [11C]-Nintedanib or [18F]-FLTPET/CT imaging.
To investigate associations between IBD severity, ASCA titer, microbiota composition and C. albicans strains present in feces.
To study sensory processing and hyperexcitability in children with ASD and epilepsy using neurophysiological measurements (EEG/ERP).
Does humoral and/or cellular rejection play a role in recurrent miscarriage of unknown etiology?Can biomarkers of humoral and/or cellular rejection be used for the detection of patients who are likely to suffer a miscarriage in a next pregnancy?
The aim of the project is to examine the association between clinical, environmental and genetic characteristics of the recipient of erythrocyte transfusions and the risk or resistance to immunization against erythrocyte alloantigens that he/she was…
To assess the number of patients in remission, 12 months after dose adjustment of IFX from 5mg/kg to 3 mg/kg. Secondary objectives include: number of relapses, defined by increase of fecal calprotectin and/or CRP and clinical activity, subsequently…
The primary objective of CDfuture is to provide duodenal biopsies of patients with and without CD, and venous blood samples, to continue CD research as described above.
Primary Objective: to study the differences in CD4+ T cell subsets (Th1/Th2/Th17/Tregulatory/Tsenescent) between GCA patients and healthy controls at diagnosis and during follow up and in remission. Secondary Objective(s): - To characterize the cell…
The purpose of this investigation is to evaluate decellularized homograft for aortic valve replacement (ARISE AV) rates in comparison to current valve substitutes within a large prospective multicentre surveillance at 6 leading European Centres for…
The primary objectives of this proposal are:- to reveal specific abnormalities on resting state fMRI activity of the DMN and connectivity between DMN, medial temporal lobe structures and perceptual cortices related to the pathophysiology of…
The overall aim of this study is to elucidate the neural correlates of the effect of social exclusion on social decision-making in chronically rejected and stable accepted children. The secondary aim is to investigate whether deviant sensitivity…