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In this study we will therefore investigate the influence of hypoxia and anti oxidants on HVR and HPV.
The primary objective of this clinical controlled trial is to define the overall effect of adenocorticotropic hormone on coagulation parameters in patients with primary adrenal insufficiency (as diagnosed by their physician by previous short ACTH…
Primary Objective: comparing hemodynamic stability provided by titration of esmolol in addition to standard perioperative care including low-dose metoprolol to placebo and standard care.Secondary Objective(s): -comparing the incidence of…
Examine how unexpected reward and unexpected punishment affect working memory, that is, the ability to maintain information across time, update task-relevant information and ignore task-irrelevant information.Determine the extent to which…
to measure peripheral insulin sensitivity and intramyocellular concentrations of different FA metabolites (ceramide, gangliosides, diacylglycerol and triacylglycerol) known to interfere with the insulin signalling cascade during infusion of…
We aim to study the short-term effects of postprandial hyperglycemia in patients with impaired fasting glucose and in patients with T2DM on aortic stiffness as measured by PWV. Secondly, we study the effects of postprandial hyperglycemia on the…
The objectives of the study are to investigate the acute effects of a single consumption of tomato ketchup on ex-vivo elicited inflammation (release of the cytokines TNF-α, IL-8 and IL-10 upon LPS stimulation), chemotaxis of monocytes ex-vivo and on…
> Primary Objective:This is a pilot study, aiming at the clinical evaluation with respect to safety and feasibility of a one-step surgical procedure for maxillary sinus floor augmentation for the placement of dental implants, using a ceramic…
To test the gastric emptying properties of a whisked drink.
In this pilot study, the time course of the increase in blood plasma levels of uridine after single intake of UMP and UMP-enriched products will be explored in healthy volunteers. Five intervention groups will be studied; three intervention groups…
The main objective of the current study is to determine the short-term effects of a glucose drink and a sacharose drink on memory, attention and mood in elderly men women.
To investigate the efficacy of repeated daily doses of nebulised RPL554 (0.018 mg/kg) by assessing the effect on FEV1 at day 1, 3 and 6 after daily inhaled doses of nebulised RPL554 0.018 mg/kg (6X) in 16 allergic asthmatics.
To investigate if the GH-promoting effect of gelatine- protein is present in non-overweight and overweight elderly people.
In this studie we wish to examine the FGF-23 suppressive effects of calcitonin in healthy men.
As a result of the vele symptoms which can appear at these patientengroep several diagnoses to be mostly put because many occupational groups occupy themselves such as dentists, dental surgeons, chiropraktikers, osteopaten and fysiotherapeuten,…
To measure the effect of folic acid supplementation on heme iron absorption in vivo.
In the present study the effects of the colonic administration of butyrate on portal, hepatic, mesenteric venous and arterial SCFA concentrations will be studied in patients undergoing major upper abdominal surgery. The aim is to clarify the…
We hypothesize, that during an oral glucose tolerance test, the OPS arterial flow measured sublingual will be comparable within the same subject, but different between young, elderly and type 2 diabetic patients. Objective is to quantify differences…
The primary objective of the study is to investigate the effect of sunitinib on ex-vivo atrial contractile force in absence and presence of ischemia-reperfusion. A secondary objective is to explore if atorvastatin or AICAR prevent sunitinib-induced…
Part I: The objective of Part I of this study is the efficacy of a single 5-g and 10-g dose of InsuVital* on blood levels of insulin and glucose in patients with T2DM.Part II: The objective of Part II of this study is to assess the effect of a 10-g…