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Assessing and predicting functional and quality of life-related outcomes of islet and pancreatic transplantation in patients with type 1 diabetes mellitus

There are two objectives for this study: first, to find specific serum beta cell damage markers that can serve as a clinical predictive tool for beta cell allograft loss. Second, to compare quality of life and diabetes-related outcomes in patients…

PreCARA: Preconception Counselling in Active Rheumatoid Artritis and other chronic inflammatory arthritides;
Preconception counselling for women with rheumatoid arthritis (RA) or another chronic inflammatory arthritis and a pregnancy wish, which is evaluated in a prospective observational study monitoring pregnancy, delivery, postpartum period of the mother, and (growth) parameters of the child.

In the present study we will evaluate the standardized care protocol developed in our outpatient clinic, intended to guide counselling for medication use prior to pregnancy. This protocol guides treatment decisions based on disease activity,…

A Multicenter randomized trial, comparing a 25G EUS Fine Needle Aspiration (FNA) device with a 20G EUS ProCore Fine Needle Biopsy (FNB) device

To compare the performance and diagnostic accuracy of two EUS-guided tissue acquisition devices; a 25G Echotip Ultra Fine Needle Aspiration (FNA) device and a new, more flexible, 20G Echotip ProCore Fine Needle Biopsy (FNB) device.

The neural signature of self-concept development in adolescence in relation to romantic relations and sexuality in youth

Original study:The goal of this study is to have a theoretically based understanding of how sub processes of self-concept development emerge in relation to each other. The primary objective is to test a neuroscientific model of self-concept…

The long-term follow-up interferon-α treatment for chronic hepatitis B infection

To study the long-term effects of interferon-α treatment for chronic hepatitis B patients infection.

A proof of concept study for [18F]FB-IL2 PET imaging of infiltrating T cells after renal transplantation; a diagnostic tool for acute rejection

To investigate if [18F]FB-IL2 PET/CT is able to detect acute allograft rejection in kidney transplantation patients.

The clinical prognostic value of the carotid artery reactivity test in patients with peripheral artery disease

To examine the 1- and 3-year prognostic value of the CAR-test in patients with peripheral artery disease regarding the occurrence of vascular complications and the progression of PAD

Synovial tissue analysis of factors related to bone-destruction and bone-production in patients with knee arthritis

Aim of this study is to obtain synovial tissue and synovial fluid, from 80 patients with non-septic, inflammatory knee arthritis undergoing routine arthroscopy of the knee and analyze inflammatory factors influencing osteoclast and osteoblast…

Brain specific proteins in tissue macrophages in acute ischemic stroke. Association with functional and radiological outcome; a pilot study.

To investigate whether the amount of TiMas containing brain specific proteins, correlates with functional outcome and infarct size in patients with acute ischemic stroke. And, to study the kinetics of the tissue macrophages and to compare these data…

Screening of Hindustani people for risk factors of cardiovascular disease

The primary objective of this study is to assess the CV risk profile of Hindustanis without known diabetes mellitus (DM), hypertension, dyslipidemia or CV disease and evaluate the 10-year CV risk according to the Framingham risk score. Secondary…

Registry of the treatment of primary insufficiency of the great saphenous vein with a diameter >/= 12 mm, antero-lateral branches, or great saphenous vein insufficiency below the knee with mechano-chemical endovenous ablation (MOCA)

The goal of this registry study is to provide insight in the safety and efficacy of treatment with MOCA for primary insufficiency of the GSV with a diameter >/=12mm, insufficient antero-lateral branches (<12 mm) and insifficincy of the…

The influence of oral contraception on the 1 mg overnight dexamethasone suppression test

1. Examen if the outcome of the 1 mg Overnight Dexamethasone suppression test is influenced by the use of oral contraception.2. Examen how many weeks after ceasing the use of orale contraception the 1 mg Overnight Dexamethason suppression test is…

European Non-invasive Trisomy Evaluation (EU-NITE Study): Evaluation of a targeted analysis of cell free fetal DNA in maternal blood for prenatal diagnosis of fetal trisomies.

our primary aim is to validate a targeted analysis of circulating DNA in maternal blood by assessing the diagnostic accuracy for fetal trisomy 21. In addition, test characteristics for fetal trisomy 18 detection will be evaluated.

Effects of bosentan in a homogeneous population of SSc subjects with a predefined restriction of blood flow in the hands

The primary objectives are:- To demonstrate the relationship of blood flow in the hands and the extent of digital ulcera in patients with systemic scleroderma;- Evaluate the effect of bosentan on the blood flow in the hands from baseline to 12 weeks…

A phase 1, placebo-controlled, ascending-dose study to assess the safety and imaging characteristics of GE-137 Injection in healthy volunteers, and to assess its safety and imaging characteristics in subjects with high suspicion of colorectal cancer

The study the safety and imaging characteristics of GE-137

Flexor Carpi Ulnaris Innervation Zone Localization using High-density Surface Electromyography

The aim of this research is to determine whether HDsEMG could be used as a reliable alternative to a current clinical procedure of lower arm muscle innervation zone localization.

Randomized clinical trial on the performance of direct and indirect composite restorations in patients with severe tooth wear

Aim of this study is to investigate the clinical performance of two restoration techniques, making use of 'direct' and an 'indirect' composite restorations as a minimal invasive intervention in patients with severe tooth wear.…

Hyperglycaemia and Ambulatory Anaesthesia

In this study we want to prospectively investigate in a large ambulatory surgical cohort in which patients glucose levels increase during surgery and whether this is related to postoperative complications.

Serum allergens and innate lymphoid cells in eosinophilic esophagitis.

Primary: to analyze serum samples of adult EoE patients for IgE reactivity to recombinant allergens of common foods.Secondary: to demonstrate the presence of ILC2 in periferal blood of adult patients with eosinophilic esophagitis Tertiary: To store…

A study to evaluate the response of whole blood stimulation with lipopolysaccharide or other inducers and its in vitro inhibition in healthy volunteers, and patients with a chronic inflammatory condition

At CHDR, experience has been gained with the assessment of the in vitro inhibition by MAP kinases of the LPS-induced TNFα release in healthy male volunteers. However, relatively little is known on the inhibition by MAP-kinases in other populations.…