28 results
Primary: • To evaluate the sensitivity and specificity of DWI-MRI to identify patients who will develop local failure after radio-chemotherapy of cervix cancer.Secondary: • To evaluate the sensitivity and specificity of MRI techniques including (T2-…
To establish the changes in tumour diffusion hyperthermia induces in humans.
This study is to answer two questions. First the acceptability and ease of use of the modified version of he Delphi Screener in general and in different body positions. Second the confirmation of a sufficient yield of cervicovaginal cells by self…
This study will be conducted to determine the overall hr-HPV agreement between self-sampled cervicovaginal smear (Evalyn Brush) and physician-obtained samples taken by a trained physician (liquid based cervical smear) in a screening population. The…
Implement a survey initiative to assess HIV prevalence for one or more diseases and/or conditions within a specific segment of the population not yet diagnosed with HIV and that present for care with the specific disease/condition.
To determine sensitivity, specificity, positive predictive value and negative predictive value of the spectroscopic cervical imaging device in detection of high grade cervical intraepithelial neoplasia.
Primary objectives:- Evaluate colposcopic visual appearance of cervical lesions in relation to its histological substrate, HPV genotype(s) and molecular parameters.- Study cervical disease on the lesion level using HPV genotyping and other viral…
The primary objectives of our study are: - Determining the long-term predictive value of a positive HPV test for (pre)malignant cervical disease.- Determining the long-term protective value of a negative HPV test. - Determining the long-term…
The primary objective is to determine the positive and negative predictive value of an hrHPV test after treatment for the development of recurrent (cervical) disease on the long term.
To investigate whether hyperthermia induces HR-deficiency in cervical tumors and as a feasibility study, secondly to investigate whether it is possible to detect circulating tumor cells before and after hyperthermia.
Our primary objective is to determine whether testing for molecular markers, i.e. hrHPV, methylationmarkers , i.a. CADM1/MAL and combinations thereof, yields a higher sensitivity and specificity for the detection of CIN2/3 or cancer after treatment…
To determine the accuracy of MRI with DWI in detecting residual disease in patients with uterine cervical cancer treated with (chemo)radiotherapy.To determine the additional value of using DWI to a standard MRI protocol.To evaluate in the inter-…
The aim of the vaginal morbidity sub-study is to better understand the different physical, dosimetric, biological, clinical and psychological factors and to analyse the importance of these factors for patient reported outcome on sexual functioning…
To identify molecular alterations associated with cervical tumorigenesis, that could be used as biomarker for improving detection and differentiation between cervical cancer, cervical intraepithelial neoplasia and normal cervical tissue.
Evaluation of the capacity of a HPV 16 peptide vaccine to install a long term HPV-specific T cell response, to define the importance of a booster vaccine after 1 year, the induction of Cytotoxic T lymphocyte (CTL) immunity against HPV16E6 and E7 and…
This study aims to reveal whether vaccination of women with HPV 16+ cervical intraepithelial neoplasia not only results in a strong systemic T-cell response, but also endows these T-cells with the capacity to infiltrate HPV16-induced lesions.…
Visualization of the MGU and it*s borders on MRI scans of women without cervical cancer.
To develop and in vivo optimize T2w ultra high field (7T) MRI sequences, which use a combination of an endorectal and external coil, to image the (para)cervical area for assessment of the loco-regional tumor status in cervical cancer.
In the proposed project, we will conduct a clinical phase I trial with cervical cancer patients, scheduled to undergo radical hysterectomy and pelvic lymphadenectomy, to assess the safety and toxicity as primary endpoints and, as an explorative…
Primary objective:- Disease free survival (DFS)Secondary objective:- Safety & tolerability- Overall survival (OS)Exploratory objective:- Association between HPV subtypes and efficacy- Patient reported outcomes (PRO)Please refer to section 1…