836 results
To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.
Primary Objective: To determine the accumulation of AGEs in the skin and serum of pregnant women with DM1, DM2 or GDM, in comparison to healthy pregnant women and non-pregnant women with DM1 or DM2 and to determine the accumulation of AGEs in the…
Discover diagnostic biomarkers for disease severity. Increase the insight in the epidemiology of viral infections in the primary, secondary and tertiary care facilities and in the pathogenesis of and immunological response against viral infections.
The aim of this study is to demonstrate which is the most effective operation for neonates with necrotizing enterocolitis (NEC): intestinal resection with stoma formation or intestinal resection with primary anastomosis.
To investigate the relation between a known genetic variation in a set of selected genes involved in the recognition of microorganisms and inflammation and the frequency of respiratory tract infections in a group of children with DS.
The objective of this pivotal study is to assess the PK and PD as well as safety and tolerability of RP103 compared to Cystagon® in patients with nephropathic cystinosis. Results of this Phase 3 study will be used to support the registration…
The aim of this study is to improve insight in potentially genetic factors contributing to the development of pyloric stenosis.We aim to investigate the association of the COL3A1 gene and pyloric stenosis because of concrete signs in the existing…
To study whether microcirculatory perfusion is improved by ECMO. Perfusion will be studied before & after ECMO start, during ECMO weaning and before & after ECMO stop. To study the precictive value of perfusion and its correlation…
Objective: This study aims to investigate, whether children with clubfeet are facing difficulties in daily life on activity*s and participation, two domains of the ICF, comparing to their age-mates without clubfeet.
The objective of the study is to improve the trained as wel as other executieve functions. Also the aim of this study is that these functions will improve in everyday life and generalize to other domains, resulting in improvement in behavior,…
Hypothesis:A substantial proportion of the JIA patients in remission (according to the Wallace criteria) will be able to discontinue etanercept successfully.Goals:To investigate in a randomized controlled trial:- which proportion of JIA patients in…
The objective of the studie is to develop a reliable and discriminative measurment protocol to determine the upper extremity function in boys with DMD. This measurement protocol will be based on 3D movement analysis and surface EMG measurements.
The objective of this study is to analyse the association between stress and obesity in children. We hypothesize that obese children have higher levels of stress than normal weight controls. The key objective is to study differences in stress levels…
To evaluate the predictive value of microcirculatory perfusion for the incidence of Extracorporeal Membrane Oxygenation (ECMO) dependency and consequently survival. To evaluate the effects of vasopressor drugs and iNO on microcirculatory perfusion.
Evaluating the current dosing guidelines in children taking the half-strength paediatric tablets will provide reassurance that the recommended lopinavir/ritonavir dose provides adequate drug exposure and maintains efficacy.This trial will evaluate…
To compare neonatal mortality and short-term (advanced MRI indices of structural brain injury at 40 weeks* GA) and long-term neurodevelopmental outcomes (Bayley scales of infant development III [BSID-III] at 24 months) between two groups of very…
To evaluate the safety, tolerability, protein accretion, amino acid plasma levels and long-term outcome of Neoven compared to Vaminolact in preterm infants with a birth weight from 800 g to less than 1500 g and with a gestational age from 25 weeks…
The aim of the study is to evaluate the effectiveness of the Incredible Years (IY) training to reduce behavior problems in young children. Also, the effect of IY on parenting skills and parenting stress will be examined.
The main aim of this project is to identify genetic and metabolic risk factors for mild MR and borderline intelligence.
To assess the effect of bilateral cochlear implantation compared to the standard unilateral cochlear implantation in children with severe to profound hearing loss.