15 results
To gain further insight into the interaction and possibly shared pathophysiological mechanisms of female-specific cardiovascular risk factors and events we will quantify white matter hyperintensities on brain MRI and assess endothelial function in…
1. To identify presymptomatic and symptomatic profiles including (early) disease stages and early biomarkers of disease progression and to elucidate pathophysiological mechanisms, we will investigate RVCL patients at different ages (both symptomatic…
Measuring the thickness of the microvascular glycocalyx, and make a comparement between lacunar stroke patients and healthy controls.We also compare glycocalyx between patients with and without concomitant silent signs of cSVD on brain MRI.
To develop pulse transit time into a diagnostic device which can be used to assess an altered cold/heat mediated vasomotor response (CHMV) (central component) and the flow-mediated dilatation (FMD) (peripheral component) in CRPS patients.
To describe the differences in macrophage infiltration and mRNA expression of adipocytokines in subcutaneous, omental and perirenal fat tissue in Cushing's syndrome compared to healthy controls.
To identify some of the mechanisms in patients in remission of Cushing*s syndrome that contribute to the persistence of visceral obesity, systemic inflammation, insulin resistance, sarcopenia, a low muscle oxidative capacity and increased risk of…
Our overall objective is to better understand the role of regulatory B cells in disease pathogenesis and to better predict disease flares in order to individualize treatment.
1. To assess neuroimaging hallmarks of RVCL disease stages;2. To evaluate cerebrovascular reactivity as a biomarker of endothelial (dys)function in RVCL patients, in migraine patients and healthy controls;3. To identify shared pathophysiological…
To determine the vaginal microbiota composition during preeclampsia
To assess the feasibility of measuring a course in ischemia and endothelial activation in antecubital venous blood during cooling and recovery in patients Raynaud*s phenomenon, primary and secondary to SSc with and without Pulmonary Arterial…
The primary objective is to determine and compare the microvascular status between middle-aged women with and without migraine. Secondary objectives include a determination of the agreement and reproducibility of two devices which measure the blood…
1. to describe NVC findings in patients with pediatric (systemic) auto-immune/-inflammatory diseases:- Juvenile systemic/localized sclerosis (jSSc/lSc)- Childhood-onset systemic lupus erythematosus (cSLE)- Juvenile dermatomyositis (JDM)- Juvenile…
The primary objective is to identify clinical and biological measures that discriminate paediatric ME/CFS and post-COVID patients from healthy controls based on either clinical (based on physiological tests and questionnaires) and biological (based…
Primary Objective: Primary: Gut microbiota (oral and fecal) and nasal microbiota composition in relation to autoimmunity status (antibodies (ANA, ANCA) and HLA subtype) and inflammatory functional assays as well as disease activity parameters in…
In this study, we therefore aim to investigate how trained immunity is systemically regulated in ANCA vasculitis patients and how the degree of trained immunity affects disease activity and severity. A better understanding of these processes…