24 results
The primary objective of the study is to determine whether patients with PA have a higher level of arterial wall inflammation than patients with essential hypertension. Secondary Objectives: To determine whether circulating monocytes of patients…
Main objective of this pilot study is to investigate the placental bed histological phenotype and evaluate a scoring system for lesion characteristics of the placental bed spiral artery in pre-eclampsia and uncomplicated pregnancy. The secondary…
W want to investigate the influence of a mutaion in the MH allel on the HPV and the normal reaction of MH patients to hypoxia
Main objective of this pilot study is to compare vascular lesions of the placental bed spiral artery characteristics in pre-eclampsia to spiral artery samples after an uncomplicated pregnancy. Aim of the pilot study will also be to determine the…
The present study has 2 primary objectives: 1: The first aim of the present study is to explore early detection possibilities using plasma hemopexin activity and plasma ATP levels in cohorts of pregnant women in a time course manner (experiment 1).…
1. Does mPAT directly impair vasoreactivity to insulin and acetylcholine ex vivo in arterioles obtained from muscle biopsy in lean and obese individuals?2. Is obesity in humans associated with the accumulation of mPAT and an inflammatory mPAT…
Is recurrent miscarriage an independent risk factor for an increased cardiovascular risk?
In this study, we will assess whether healthy and hypertensive subjects with high-normal serum CK display greater salt retention and vascular contractility, compared to those with low-normal serum CK.
Primary objective:• To investigate whether physical exercise prior to pregnancy in formerly preeclamptic women results in a comparable improvement of vascular and endothelial functioning as in women who had an uneventful pregnancy.Secondary…
Our primary objective is to compare the changes in renal vascular resistance in 10 years between women with a history of preeclampsia and controls.
To study the effects of physical training on vascular, endothelial and immunologic functioning in women with recurrent miscarriage; results are compared with women who have never been pregnant (nulligravid controls) and women who have a history of…
To investigate the genetic, genomic and proteomic basis of hypertension and susceptibility to hypertension-related target-organ damage (renal insufficiency and heart failure).
To determine the underlying mechanisms responsible for thiazide-induced hyponatraemia and to identify (elderly) patients who are at risk of this potentially life-threatening complication.
To study etnic differences in contractillity of the smooth muscle and to investigate the role of CK in this proces.
1. to investigate early haemodynamic alterations and endothelial function in young prehypertensive medical students; 2. to examine the possbility to improve these haemodynamic changes after exposure to an endothelial dependent (salbutamol) and…
The primary endpoint will be descriptive histology on placental bed biopsies and placenta in healthy pregnant women or women with preeclampsia and/or IUGR in need of caesarean section. In particular, the study will aim to find the degree of…
Primary Objective: 1. to determine unique inflammatory VOC profiles that distinguish patients with PAH-CTD, CTEPH and IPAH from SSc and SLE (CTD) patients without PAH. Secondary objectives:1. to test whether these unique inflammatory VOCs associates…
Research question: Is maternal microbiome dysbiosis in MOB an underlying mechanism in the pathophysiology of adverse maternal pregnancy and offspring outcome?Objectives: Analyse the differences between the gut and vaginal microbiome, maternal and…
Part I- To determine the impact of PE on incidence of macro-and micro-vascular dysfunction reflected by surrogate measures for coronary artery disease (CAD) and HFpEF, and potential deterioration over time.- To perform a genome wide association…
The precise pathophysiology for hypertension causing brain damage is still unclear, although microvascular dysfunction is thought to play an important role. Therefore, in this study the small cerebral vessels will be studied in more detail. The main…