36 results
In this exploratory pilot study, we aim to investigate the role of immune activation in osteoporosis in HIV-infected patients on HAART with proven osteoporosis/ osteopenia in comparison to HIV-infected patients on HAART without osteoporosis/…
The objective of this study is to gain insight in HIV infected children in the AMC in:.- the prevalence and clinical signs of livertoxicity - an association between the different compounds of combination anti-retroviral therapy (cART) and…
To identify human genetic variants that influence susceptibility or resistance to HIV infection
To evaluate neurologic- and cognitive disorders, neuroimaging and ophthalmological alterations in perinatally HIV-infected children in comparison to matched (with respect to age, sex, race, home environment and socio-economic status) healthy…
To elucidate the pathogenetic mechanism of endothelial cell activation in DENV infected patients with sickle cell disorder.
To suppress low-level viremia to a level below 50cp/mL in patients using cART by switching their current non-nucleoside reverse transcriptase inhibitor (NNRTI) or PI to DRV boosted with ritonavir (RTV) (DRV/r). Secondary objectives are to reduce the…
Discover diagnostic biomarkers for disease severity. Increase the insight in the epidemiology of viral infections in the primary, secondary and tertiary care facilities and in the pathogenesis of and immunological response against viral infections.
The aim of this study is to determine the risk factors in infants for obtaining a severe HPeV infection. For this purpose, we will test the hypothesis that (maternal) HPeV specific antibodies are protective against (severe) HPeV infections in young…
With this project we aim to clarify the differences in airway pathophysiology between asthmatics and healthy controls that underlie the prolonged survival of virus and the exaggerated inflammation in virus-induced exacerbations of asthma. We will…
The primary objective is whether a difference in innate and acquired immunorespons on RSV infection exists, in children with DS compared to healthy matched-controls.
To set up a cohort of HIV infected MSM who subsequently acquired HCV infection with a known date of HCV seroconversion to study:- determinants/risk factors for acquiring HCV in HIV infected MSM- the outcome of HCV treatment in this population- the…
The general objective of this study is to elucidate the cellular components for HIV-1 infection in children.
The objective of this research is to identify genetic host factors influencing the clinical course and treatment of HIV infection. The identification of these genes may lead to new therapeutic or preventive approaches. In addition, the…
1. To investigate the etiology and incidence of respiratory tract infection in children younger than 6 years of age.2. To investigate the course of respiratory tract infections in children younger than 6 years of age.3. To investigate the clinical…
Investigate whether switch from a non-nucleoside reverse transcriptase inhibitor (NNRTI)- or protease inhibitor (PI)-based regimen to a raltegravir-based regimen results in reduced platelet reactivity, reduced platelet-leukocyte aggregate formation…
To increase insight in cerebral injury of perinatally HIV-infected children by comparing neurological, ophtalmological and neurocognitive outcomes to those of matched controls (with respect to age, sex, ethnic background, home environment and socio-…
Primary objective:Investigate if a trained immunity profile in innate immune cells might be a mechanism of HIV elite control.Secondary objectives:1. Determine the immune phenotypes that distinguishes family members of HIV elite controllers from…
1. To evaluate if breastmilk of mothers who recovered from a proven COVID-19 infection contains antibodies (IgA) against SARS-CoV2.2. To evaluate if these antibodies are still present after pasteurization according the Holder method.
The aim of this study is to determine whether white blood cells from pregnant women are more susceptible to infection with the Zika virus compared to white blood cells from non-pregnant women. We do this by collecting two tubes of blood from…
We aim to characterize innate anti-viral defence responses in the upper airways of COPD patients.