91 results
We aim to answer the following research questions: 1. Is there an association between trauma and psychopathology in children? In answering this question we will compare cases to their healthy siblings, cases to controls, and siblings to controls. 2…
The following hypotheses are tested in the current study: 1) Metacognitive training is more effective than the standard treatment (TAU) for changing paranoid thinking in patients with psychotic disorders. Subhypothesis: 1a) Metacognitive training is…
To assess microglial activation in first episode patients with psychotic symptoms and first episode medication naïve patients with psychotic symptoms compared to healthy controls using the positron emission tomography (PET) tracer [11C]-R-PK11195.
This study aims to investigate the effectiveness of the CARe methodology in terms of rehabilitation, participation, empowerment, hope and confidence, fullfilled needs for care and quality of life. The central research question is: *Does the support…
The objective of this study is to directly test, in humans, the hypothesis that reduced prefrontral control leads to dysregulation of the striatum.
The goal of the proposed work is to understand dysfunction in two components of cognitive control in schizophrenia: response inhibition and monitoring. The aims of this project are to behaviourally characterize response inhibition and monitoring…
The objective of this study is to see wether the use of eye movement treatment (EMDR) reduces the emotionality en vividness of imagery (mental images) above 'recall only'. This is a first study which may be the predecessor of a larger…
To examine whether hearing impaired young adults are sensitised to social stress, whether this related to dopaminergic activity and whether theory of mind could mediate the relationship.
Hypotheses of the study:Psycho-education coping skills training is effective in reducing the negative consequences of stigma in people with SMI, in a way thata) quality of life of people with SMI improves;b) social functioning of people with SMI…
Obsessive compulsive symptoms in psychosis: Insight into dynamic interaction and symptom variability
With this research project we aim to investigate the time course and relationship between psychotic, obsessive-compulsive and depressive symptoms and the influence of environmental and individual factors on the course of symptom severity and…
In this project, I wish to take a novel step in understanding the influence of environmental exposures in the aetiology of psychotic disorders, by studying occurrence of (minor) psychotic symptoms and the (correlates of) physiological indicators of…
The main goal of our proposal is to study the interaction between cognitive and emotional capacities in schizophrenia. In numerous studies patients with schizophrenia show impairments in all major cognitive domains (6) as well as impairments in the…
The aim of the current study is to investigate which gene-abnormalities can be related to brain deficits and symptoms associated with schizophrenia.
Primary objective: To evaluate the influence of fosamprenavir/ritonavir on single-dose pharmacokinetics of olanzapine in healthy volunteersSecondary objective: To evaluate the safety of fosamprenavir/ritonavir combined with single-dose olanzapine in…
Primary ObjectivesThe primary objective is to assess the efficacy (primarily through time to relapse) of long-acting injectable (LAI) paliperidone palmitate compared to treatment as usual with orally administered antipsychotics in monotherapy over…
The aim of the proposed research is to test the hypothesis that lack of insight in psychosis is associated with reduced activation of brain circuits subserving self-evaluation and emotion regulation and that this relationship is also dependent on…
Primary research questions: 1. Is there a difference in effectiveness of clozapine treatment compared to olanzapine treatment in the reduction of substance use disorders of patients with schizophrenia and related psychotic disorders? 2. What is the…
To investigate whether patients with schizophrenia show reliable and consistent brain activations as measured with fMRI to two different stimulation paradigms and wether they differ in terms of the patterns or the intensity of activation as compared…
The aim of the present study is to investigate the semantic network of patients with psychosis with current auditive hallucinations, patients with psychosis without current auditive hallucinations, first degree relatives of patients with psychosis…
The aim of the project is to apply neuro-economics in order to elucidate mechanisms underlying disturbed social cognition in paranoid delusions at the level of the cognitive mechanisms. This will be done in patients with lifetime presence of non-…