258 results
The overall objective of this study is to investigate both the efficacy as well as the safety of combined and prolonged use of S&SEs - as part of a healthy diet - in a population of overweight/obese adults and children.
Primary Objective: to compare improvement in arthrosis symptoms between patients operated with ROSA-assistance and conventionally operated patients.Secondary Objective(s): to compare clinical, procedural, logistic and economic outcomes between…
Unravel the working of the immune system in South Asians, specifically the monocytes. We will also study whether the release of incretin hormones (GLP-1 and GIP) following a meal is lower in South Asians compared to Europids. The latter we will…
To obtain insight into the metabolic and lifestyle determinants of postprandial blood glucose responses and to establish the effect of macronutrient manipulation of a 12-week dietary intervention on blood glucose homeostasis in metabolically…
The overall objective of the study is to investigate a lifestyle intervention for women with a pregnancy wish or pregnant women in their first trimester, and a high risk on perinatal morbidity because of (prepregnancy) overweight or obesity. With an…
The primary objective is to examine the effects of dapagliflozin on nocturnal substrate oxidation in overweight or obese subjects with disrupted glucose homeostasis but without T2D.
The Check@Home consortium aims to set up a roadmap and infrastructure for a (cost-)effective program to early detect atrial fibrillation and chronic kidney disease (defined by elevated albuminuria) in the general population. Furthermore, the project…
Primary Objective: What is the difference in the effectiveness of the Food Pharmacy Program in glycaemic regulation compared to nutrition coaching performed by dieticians after three months in overweight adults with type 2 diabetes? Secondary…
We intend to perform a pilot study to determine the optimal nutrient mix (predominantly based on medium-chain triglycerides, MCTs) to induce a mild ketogenic state in healthy older (60-80y), overweight/obese (BMI: 25-35 kg/m2). Since the aim is to…
To determine the effect of time restricted eating in gestational diabetes on glucose metabolism.
Primary Objective:To investigate change in fat mass index between 6 and 12 months of age in infants receiving Nuturis® formula feeding versus standard formula feeding during the first 6 months of life.Secondary Objectives:- To investigate change in…
The main objective of this study is to develop and investigate the (cost-) effectiveness of a pharmacist-led personalised intervention, with E-Health components, to analyse and improve medication adherence in people with T2DM, who are non-adherent…
It is hypothesed that intervention (bariatric surgery) compared with control (life style intervention program) will increase fertility measured by the healthy born baby rate after at least 37 weeks of gestation (primary end point) within 3 years…
To provide high-quality remote care to patients with type 2 diabetes, using an eHealth platform with support from a medical service center. The present study is optimisation and implementation research. Notably, the aim is not implementation but…
To assess the impact of short-term forearm immobilization on forearm muscle glucose uptake and amino acid net balance and kinetics of individuals with T2D compared with a control group with normoglycaemia.
Primary Objective: 1. What is the efficiency of a blended care version of the POWER diet (Blended POWER), compared to the POWER diet used in usual care (usual care POWER program): is Blended POWER equally effective in reducing weight after 1 year in…
We aim to investigate the efficacy of a novel eating disorder prevention program, the Diabetes Body Project, specifically targeting young females T1D. Firstly, we will test the hypothesis that Diabetes Body Project will produce significantly greater…
Primary objectiveTo confirm the effect on glycaemic control of once weekly insulin icodec in combination with insulin aspart, in subjects with T1D. This includes comparing the difference in change from baseline in HbA1c between once weekly insulin…
The primary objective of this cohort study is to determine the prevalence of simple and progressed NAFLD in subjects at risk followed by the general practitioner The secondary objectives are:1. To study the factors linked to the development of NAFLD…
To determine safety and efficacy of low molecular weight dextran sulphate during islet transplantation