10 results
1. To investigate if PMN of patients with sickle cell disease are prone to form NET when compared to PMN of healthy controls.2. To investigate if red blood cells of sickle cell disease patients promote NET formation of PMN in sickle cell patients as…
To elucidate the pathogenetic mechanism of endothelial cell activation in DENV infected patients with sickle cell disorder.
The objective of this study is to investigate if CEC are elevated in SCD (and if they could therefore serve as a potential tool for assessing SCD activity), and what the relation of CEC is to the patients medical history and to specific laboratory…
Assessing different modalities of ektacytometry in diagnosing thalassemia and/or iron disorders. Investigating the influence of hemoglobinopathies and iron disorders on red cell membrane deformability in comoparison with healthy controls.
Primarily, to investigate whether recipient immunity is preserved and how fast it reconstitutes after non-myeloablative MSD HSCT resulting in mixed chimerism in adult SCD patients. Secondly, to investigate whether donor immunity is transferred to…
The overall aim of this project is to delineate the role of neutrophil activity and diversity in the pathogenesis of acute (e.g. vaso-occlusive crisis (VOC) and Acute chest syndrome (ACS)) and chronic complications in sickle cell didease and its…
Primary objectiveTo evaluate current clinical practice and develop a population based Campath® (Alemtuzumab) pharmacokinetics model for predicting total Alemtuzumab exposure after i.v. administration before allogeneic stem cell transplantation in…
The primary objective is to investigate the efficacy of VR, complementary to standard care, in reducing intensity of pain in SCD patients hospitalized with VOC compared to the efficacy of another distraction method (tablet use) next to standard care…
Main objective: - To investigate pyruvate kinase thermal stability in haemoglobinopathies.Secondary objectives: - To investigate the possibility of stimulation of PK activity and thermal stability by use of allosteric activators- To investigate…
The primary objective of this study is to investigate the efficacy of EMDR therapy in reducing pain interference in the life*s of children with SCD. Secondary objectives are to study the efficacy of EMDR in reducing PTSD symptoms, anxiety,…