Search for a trial

Predicting the Outcome of a Demyelinating event

PROUD is a multicentre prospective study, using clinical factors in combination with additional tests with the aim to clarify more about the aetiology and pathogenesis of MS.

'Comparative roentgen stereophotogrammetry analysis of the Taperloc stem with BoneMaster® nano-technology coating compared with cemented and uncemented HA coated Taperloc stem.'

BoneMaster ITo perform a comparative assessment between the clinical, bone remodelling, and radiographic outcomes (as measured with RSA) of the conventional Hydroxyl-Apetite (HA) Taperloc stem compared with Taperloc stem with additional BoneMaster®…

Long-Term Multi-center Evaluation of E-Poly* and Regenerex* Cementless Acetabular Components: Clinical and Radiographic Outcomes

The purposes of this long-term mutli-center study are: - To compare the long-term (10-year) radiographic and clinical outcomes of new E-Poly* liner in primary total hip arthroplasty with the conventional ArcomXL® polyethylene liner.- To compare the…

The value of MRI diagnostics in haemophilic arthropathy: a pilot study

Primary Objective: (diagnostic)• Does MRI detect structural changes of haemophilic arthropathy in knees and ankles undetected by the Pettersson score and HJHS? (Research question 1 a & b)Secondary Objective(s): (prognostic)• Can MRI predict…

Is the presence and development of microvascular disease in type 1 diabetes related to changes in brain structure and cognitive function?

Are changes in cognitive functioning related to structural changes in the brain in patients with type 1 diabetes mellitus. How are these changes related to diabetic complications like duration of chronic hypoglycaemia, disease duration and presence…

Hesitations and intentions in action

Our experiment will assess the respective role of the mirror neuron system (MNS) and theory of mind areas for understanding someone else*s immediate intentions and state of mind (prior intention). We want to test the hypothesis that making…

Explaining plasticity after stroke

EXPLICIT aims tot obtain better functional outcome by early intensive rehabilitation. Next to clinical tests to measure improvement in function, neuroplasticity is assessed by fMRI, TMS and haptic robots. The combination of clinical outcome measures…

Functional connectivity of cortico-cortical and subcortico-cortical brain networks in Parkinson*s disease

This project aims to understand the symptomatology PD in the light of functional brain interactions, in the hope of elucidating the role of the frontal striatal system to behaviour.

A study to determine the effect of post-infusion scalp cooling time in the high dose FEC-regimen

The primary aim of current study is to assess the effect of different cooling times on the efficacy of scalp cooling, thereby improving the results of scalp cooling in the high dose 5-Fluorouracil - Epirubicin - Cyclophosphamide (FEC) regimen. A…

Complications of PCOS Pregnancy: Evaluating Risk

To design a multivariate prediction model of pregnancy outcome in women with PCOS with the intention to define intervention strategies for the future.

An open label, randomized phase III trial comparing 2.5 year duration of letrozole (Femara) treatment with 5 year duration in patients previously treated for endocrine sensitive early breast cancer

PrimaryTo investigate whether 5 years of extended adjuvant treatment with letrozole results in an improved DFS compared to 2.5 years treatment in patients with early breast cancer previously treated with endocrine agents for 5 yearsSecondaryTo…

A Randomized, Open-Label, Multinational Phase 3 Trial Comparing Amrubicin Versus Topotecan in Patients With Extensive or Limited and Sensitive or Refractory Small Cell Lung Cancer After Failure of First-Line Chemotherapy

The primary objective is to demonstrate superiority in overall survival of amrubicin (40 mg/m2 administered as a 5-minute infusion once daily for 3 consecutive days starting on Day 1 of a 21-day course) compared with topotecan hydrochloride (…

Open-label, non-randomized, positron emission tomography (PET) imaging study to evaluate a single dose of 250 MBq (6.75 mCi) ZK 6032924 (18F-FEDAA1106) for its diagnostic potential in discriminating patients with probable Alzheimerâ¤*s disease from healthy volunteers and to evaluate the radiation dosimetry of a single dose of 185 MBq (5 mCi) ZK 6032924 in healthy volunteers.

Discrimination of probable AD patients from healthy volunteers by ZK 6032924 PET imaging as evaluated by visual analysis of the brain distribution patterns and by SUV values in probable AD patients as compared to healthy volunteers for brain imaging…

Characterisation of regulatory T cells and cytokine production in children diagnosed with asthma

To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.

Curved versus Straight Stem Uncemented Total Hip Arthroplasty Osteoarthritis Multicenter trial
A prospective blinded randomised controlled multicentre trial comparing the CFP stem with straight stem total hip arthroplasties for the treatment of primary osteoarthritis of the hip.

The purpose of the study is to compare the functional result of CFP stem THA with conventional uncemented straight stem THA

An Open-Label, Randomized, Phase 3 Trial to Evaluate the Efficacy and Safety of Aztreonam 75 mg Powder and Diluent for Nebuliser Solution (AZLI) versus Tobramycin Nebuliser Solution (TNS) in an Intermittent Aerosolized Antibiotic Regimen, in subjects with Cystic Fibrosis followed by an Open Label, Single Arm Extension

The primary objective of this study is to assess the comparative safety and efficacy ofAztreonam Lysine for Inhalation (AZLI) and Tobramycin Nebuliser Solution (TNS) in adultand pediatric cystic fibrosis (CF) patients aged 6 years or older with…

Outcome study on gender identity, sexual functioning and psychological well being in patients with a disorder of sexual differentiation

In this study the prevalence and kind of sexual and psychosexual problems will be assessed. Psychological well being is studied as well

Functional MRI of cognitive control in autism

We intend to study the role of fronto-striatal circuitry and cognitive control in the inflexible behaviour that is a defining feature of autism.

Pathogenesis of community-acquired pneumonia, chronic obstructive pulmonary disease and cystic fibrosis: mechanism of inflammatory response and the role of Th17 differentiation

To assess whether Th17 cells play a central role in COPD, CF and pneumonia pathogenesis

Smellprints in lung Cancer; the role of ENose in diagnosis and Treatment (SCENT):
part 1. Differences in smellprints between patients with lung cancer and breast cancer

Primairy objective: we will examine the difference in VOC pattern of exhaled air between patients with histology-confirmed diagnoses of non small cell lung cancer vs breast cancer. Secundairy objective: a. to confirm the potential of the electronic…