42 results
To draw definite conclusions about the effectiveness of omega-3 PUFA supplementation in anorexia nervosa patients a double-blinded, placebo-controlled randomized controlled trial (RCT) with a substantial sample size should be conducted. Prior to…
Primary* To evaluate the pharmacokinetics of oxybutynin and its main hepatic metabolite N-desethyloxybutynin after pulsed intra-vaginal delivery of a single dose of oxybutyninSecondary* To assess the safety and tolerability of the intra-vaginal…
To determine if paracetamol can be used effectively and accurately in determining plasma volume as compared to the gold standard of 125I labeled ablumin in a non-pregnant patient population scheduled for plasmavolume measurement by I-125.
Primary objective:To evaluate the clinical efficacy and side effects (adverse events) of a single dose stereotactic radiotherapy on the electro-anatomical arrhythmia substrate, inaccessible by the current state of the art catheter ablation…
Primary objective: to assess the relation of an ex vivo functional assay for tumor radiosensitivity with clinical tumor response of OPC patients treated with (chemo/bio-)radiotherapy at 3 months after treatment.Secondary objectives: - to assess the…
The aim is to develop a method that can be used to determine, already in the ambulance, whether a patient suffers a stroke and if so, what the cause of stroke is. In this project we want to develop nanotechnology that is capable of detecting…
The aim of this study is to investigate the effect of discrete vibrotactile feedback of mediolateral weight shift and step initiation for complete SCI patients on the use of an exoskeleton.
Primary objectives:• to assess the safety of combining nivolumab, ipilimumab and up to 3 fractions of medium dose hypofractionated radiotherapy (mRT) to multiple tumor sites (1 to 4, with at least 1 site receiving 24Gy)• to explore the efficacy of…
The primary aim of this explorative study is to compare exercise-induced cardiac troponin elevations between athletes with different levels of coronary atherosclerosis. The secondary aim is to compare exercise responses to other cardiac biomarkers…
Our primary objective is to determine whether adherence to Dutch dietary guidelines is associated with quality of life in patients with IBD. Secondary objectives are to evaluate the adherence of IBD patients to Dutch dietary guidelines, whether use…
1. To determine the feasibility of SGM-101 for intraoperative imaging of colorectal lung metastases - Concordance between fluorescent signal and tumor status of resected tissue2. To define the optimal dose of SGM-101 for intraoperative imaging of…
To evaluate the vestibular function relating results to surgery, radiotherapy, active surveillance, intratympanic gentamicin, and intratympanic gentamicin followed by active treatment based on objective vestibular testing and dizziness related QoL.
Examination of the test-retest reliability (two weeks) and measurement errors of the recently developed and validated self-report generalized pain questionnaire (GPQ).
• to assess the efficacy of the sequential combination strategy of front-line afatinib-chemo, followed by a treatment with osimertinib-chemo in those patients that develop a T790M mutation as a mechanism of resistance.
Objective: To evaluate the humoral response and estimate the prevalence of antibodies against SARS-CoV2 in children during the COVID-19 outbreak in the Netherlands.
The primary objective is to compare18F-MFBG PET-CT imaging for neuroblastoma patients with the current standard of imaging, 123I-MIBG SPECT, using the SIOPEN score for skeletal lesions and the number of detected soft tissue lesions as endpoints.
In this study we aim to investigate which pathways in septic patients exacerbate endothelial injury and dysfunction, furthermore do we want to investigate to what extent, and due to which components plasma transfusion can improve the endothelial…
• To measure the quality of the red blood cells of redon drain blood before and after cell saver processing.• To measure the effects on whole redon drain blood in terms of inflammatory activation, platelet activation and blood rheology in the…
The objective of this study is to collect additional data on the performance and safety of the slowly-resorbable TIGR® mesh in patients undergoing TEP for IGRP. The study endpoints are described below.
The primary objective of this study is to investigate the feasibility of several promising outcome measures in children with AS, which may later serve as potential outcome measures for treatment studies and other research. The study*s secondary…